Marcin Kurzyna: New NEJM Trial Evaluates Catheter-Directed Thrombolysis in PE
Marcin Kurzyna, Chairman-Elect of Working Group on Pulmonary Circulation and Right Ventricular Function at European Society of Cardiology, shared a post on LinkedIn about a recent article by Josef Kroupa et al, published in The New England Journal of Medicine, adding:
“The next landmark trial in the field of interventional treatment of pulmonary embolism is coming from Czechia!
Catheter-directed thrombolysis (without ultrasound) versus anticoagulation alone in intermediate-high-risk PE with some additional ‘red flags’ in a prospective, multicenter, open-label trial.
Mortality/morbidity combined endpoint driven by clinical deterioration, without differences in mortality, but 4 deaths (1.4 percent) in the AC group versus 1 in the CDT group (0.36 percent, p=NS).
Two intracranial bleedings in CDT group versus none in AC (p=NS), but without increase of major bleeding in the CDT cohort.
No evidence for a more extensive reduction in the RV/LV ratio after 48 h in the CDT group.
Big kudos and congratulations to Josef Kroupa and the whole group!
Presented at ESC Congress and published simultaneously in NEJM.”
Title: Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism
Authors: Josef Kroupa, Martin Radvan, Jan Mrozek, Martin Sluka, Stepan Jirous, Ota Hlinomaz, Milan Pliva, Jan Pudil, Hana Voberkova, Karolina Bartoskova, Martin Poloczek, Martin Kamenik, Michal Brabec, Eva Lichnerova, Martin Hutyra, Ivo Bernat, Martin Novak, Johana Horakova, Lucie Jelinkova, Tomas Knize, Petr Tousek, Cyril Stechovsky, Filip Varhanik, Zdenek Coufal, Jiri Jarkovsky, Viktor Kocka
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 1, 2026, 18:13Ramsha Batool: Chemotherapy-Induced Anemia Impacts Quality of Life in Breast Cancer
-
Sep 1, 2026, 18:09Natalya Shynhera: Using Anemia to Teach Medical English in Real Clinical Practice
-
Sep 1, 2026, 18:06Wei Du: New Therapeutic Potential for PARP Inhibitors in MLL-Rearranged Leukemia
-
Sep 1, 2026, 18:03Tobias Tichelbäcker: PRAGUE-26 Shows Catheter Lysis Beats Anticoagulation Without Ultrasound
-
Sep 1, 2026, 18:00Baptiste Thibault: My First Publication as First Author on Ionized Calcium Monitoring Before Citrate-CRRT
-
Sep 1, 2026, 17:51Nadezhda Vasilyeva: Shifting the Boundaries of Acute Ischemic Stroke Management
-
Sep 1, 2026, 17:49Malik Ghannam: Recent Venous Thrombosis Risk Factors May Help Explain Cryptogenic Stroke in Young Adults
-
Sep 1, 2026, 17:42Rishabh Jain: Renal Artery FMD Is Managed With Balloon Angioplasty Alone
-
Sep 1, 2026, 17:42Caitlin R: The Brain’s Need to Find Patterns