Hannah Isles: Interesting Link between Aging, Serotonin, Platelets and COVID-19 Severity
Hannah Isles, Scientific Writer and Editor of Hannah Isles Editorial, shared a post on LInkedIn about a recent article by Davide Marotta, published in Science Immunology, published in Science Immunology, adding:
“Interesting link between aging, serotonin, platelets and COVID-19 severity:
A new study in Science Immunology from Matteo Iannacone, Marco De Giovanni, Davide Marotta and colleagues identifies platelet-derived serotonin as a driver of age-related lung pathology following SARS-CoV-2 infection.
Platelets from older mice released more serotonin when activated, and this was associated with platelet aggregation and fibrin deposition in the lung, contributing to respiratory dysfunction.
Blocking serotonin signaling reduced disease severity, raising the possibility of a therapeutic strategy for age-associated severe COVID-19.”
Title: Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
Authors: Davide Marotta, Chiara Perucchini, Marta Grillo, Valeria Fumagalli, Pietro Di Lucia, Jordan Rixon, Micol Ravà, Leonardo Giustini, Chiara Malpighi, Giulia D’Uonnolo, Mariangela Scavone, Violette Mouro, Caitlin Abbott, Natalia Stachura-Chyla, Francesco Andreata, Erica Scalambrino, Marigrazia Clerici, Lorena Donnici, Marika Longo Minnolo, Donato Inverso, Raffaele De Francesco, Mauro Gaya, Zaverio M. Ruggeri, Armando Tripodi, Gian Marco Podda, Luca G. Guidotti, Matteo Iannacone, Marco De Giovanni
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia
-
Oct 19, 2026, 19:42Belen Bianco: Prevention, Early Suspicion and an Interdisciplinary Approach Save Lives
-
Oct 19, 2026, 19:40Christina Chrysohoou: Catheter-Based LAAC vs OAC for Stroke Prevention in Atrial Fibrillation
-
Oct 19, 2026, 19:38Matthew Flick: A Two-Day Research Meeting on Fibrinogen, Hemostasis and Thrombosis
-
Oct 19, 2026, 19:37Hayat Saeed: Excited to Share Our Publication on the FGL1–Hepcidin Axis in Iron Homeostasis and Disease
-
Oct 19, 2026, 19:08IPAW 2026 Comes to a Close, but the Work Continues – PPTA
-
Oct 19, 2026, 17:44Paul Riley: Moderating a Webinar on Anticoagulation Monitoring
-
Oct 19, 2026, 16:36Christopher Pittman: Blood Clot Prevention Cannot End at Hospital Discharge
-
Oct 19, 2026, 16:13Javier M. Floren: When Immune Cells Move With Their Environment