Ralf Ludwig։ Testing Human-Targeted Therapies in a Human Immune System
Ralf Ludwig, Director of the Lübeck Institute of Experimental Dermatology at the University of Lübeck, shared a post on LinkedIn:
”How do you test a human-targeted therapy on a human immune system — before the first patient?
In this study we used humanized immune system (HIS) mice: animals reconstituted with human blood cells, carrying human leukocytes and human Fcγ receptors.
We induced an EBA-like skin disease and treated with the BTK inhibitor ibrutinib — and disease was significantly reduced, driven by human cells.
The model itself was established by Anja Lux and colleagues within CRC 1526, and described here: ‘A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease‘(Voss et al.)
It’s the bridge most autoimmune research still lacks: a place to ask whether a therapy actually touches human immunity in vivo — not just mouse.
We used it to test the impact of kinase inhibitors on pemphigoid diseases.”
Title 1: Targeting neutrophil signaling networks in immune complex-mediated autoimmune disease
Authors: Mareile Schlotfeldt, Colin Osterloh, Anika Kasprick, Carla Zünkeler, Mikko Armbrust, Georg Kaiser, Katharina Schulze Dieckhoff, Thorge Mester, Pia Stüssel, Nancy Ernst, Ann-Kathrin Schneider, Leonie Voss, Adrian P. Mansini, Seyed Mohammad Vahabi, Yulu Wang, Haley Gainer, Jing Li, Gestur Vidarsson, Remco Visser, Frank Petersen, Xinhua Yu, Kyle T. Amber, Anja Lux, Ralf J. Ludwig, Katja Bieber
Title 2: A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease
Authors: Leonie Voss, Katharina Maier, Stella Wagner, Ann-Kathrin Schneider, Mareile Schlotfeldt, Leon Altmann, Emir Ucgan, Lukas Hönninger, Matthias Peipp, Falk Nimmerjahn, Katja Bieber, Anja Lux
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