Carmine Siniscalchi: Could LDL Cholesterol Help Us Better Predict Bleeding Risk in Patients with VTE?
Carmine Siniscalchi, Associate Professor of Internal Medicine under the Italian National Scientific Qualification (ASN), shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in JAMA Network, adding:
“Could LDL cholesterol help us better predict bleeding risk in patients with venous thromboembolism?
I am pleased to share our study published in JAMA Network Open, based on data from the RIETE Registry.
Among 19,237 patients with VTE receiving anticoagulant therapy, LDL-C levels <70 mg/dL were associated with a 40% higher adjusted risk of bleeding during the first 90 days of anticoagulation.
Interestingly, this association was observed early during anticoagulant therapy and was independent of statin use.
These findings raise an important clinical question: could LDL-C represent an additional factor for bleeding risk stratification in patients with VTE?
Further research is needed, but our results suggest a potentially new perspective on the relationship between lipid levels, hemostasis, and anticoagulant therapy.”
Title: Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism
Authors: Carmine Siniscalchi, Tiziana Meschi, Pierpaolo Di Micco, Egidio Imbalzano, Luis Hernández-Blasco, Isabelle Mahé, José Luis Fernández-Reyes, Alberto García-Ortega, Peter Verhamme, Joaquín Alfonso-Megido, Manuel Monreal
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 11, 2026, 12:03What is ITP? Raising Awareness for Immune Thrombocytopenia – ITP Australia and New Zealand
-
Oct 11, 2026, 11:55Gauri Jayasinghe: Privileged to Serve as Resource Person for the Blood Transfusion Essentials Programme
-
Oct 11, 2026, 11:49Toby Richards: New Definitions for Iron Deficiency Delighted to Be in the USA with the New ASH Guidelines
-
Oct 11, 2026, 11:44Lesley Van Wyk: ASCP High-Yield Review – Essential Thalassemia Concepts and Differential Diagnosis
-
Oct 11, 2026, 11:37Susanne Pass: Key Takeaways from ESVS 2026 Workshops in Belgrade
-
Oct 11, 2026, 10:44Logesh. M: Managing Warfarin-Associated Recurrent Epistaxis and Anticoagulant Safety
-
Oct 11, 2026, 10:28Sébastien Béland: Validating RUDAS for Detecting Neurocognitive Impairment in Sickle Cell Disease
-
Oct 10, 2026, 17:58Archo Farzana Batool: Exploring Medical Writing Through an Article on Iron Deficiency Anemia
-
Oct 10, 2026, 17:53Assessing Frailty in Adults With Hemophilia – JTH