Alfonso J. Tafur: New Evidence on Perioperative Anticoagulation in Cancer at ISTH 2026
Alfonso J. Tafur, Board Member VAS European Independent Foundation in Angiology and Vasculearn Network, shared a post on LinkedIn:
“Excited to share work from our CAIN analysis — presenting at ISTH 2026 in Paris
Perioperative Care in Cancer
Cancer patients on blood thinners face a uniquely difficult moment when surgery can’t wait.
We pooled data from two rigorous randomized VTE trials (ADAM VTE with EVE) to ask:
What actually happens when we interrupt anticoagulation for a procedure in cancer-associated thrombosis?
What we found – 179 patients, 290 procedures:
- Bleeding risk was approximately 3 times higher with injectable LMWH (dalteparin) vs. oral apixaban
- Zero recurrent blood clots at 30 days – in any group
- Procedure ‘risk category’ alone didn’t predict who bled – the low and moderate risk group had the highest bleeding rate
The precision medicine takeaway:
Anticoagulant choice, cancer biology, and individual context all matter – and apixaban appears to offer a more manageable perioperative profile.
This is exactly the kind of individualized, data-driven decision-making that precision medicine promises — now applied to one of oncology’s most common and understudied clinical scenarios.”
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