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John Abraham։ The Role of Diagnostic Splenectomy in Unexplained Splenomegaly
John Abraham/LinkedIn
Mar 5, 2026, 17:37

John Abraham։ The Role of Diagnostic Splenectomy in Unexplained Splenomegaly

John Abraham, Assistant Professor at Christian Medical College and Hospital, shared a post on LinkedIn about a recent article by Nutan Joshi et al, published in the Indian Journal of Hematology and Blood Transfusion։

”Diagnostic Splenectomy in 2026 – Still Relevant?

A large single-center series (123 cases) from CMC Vellore revisits its role in unexplained splenomegaly.

Key Points:

  • Diagnostic yield: 72%
  • Lymphoma diagnosed: 58.5%
    – 66% B-cell NHL (mainly SMZL, DLBCL)
    – 23% T-cell
    – Subtyping possible in ~88%

Predictors? None.

Age, B symptoms, LDH, splenic size, focal lesions — not reliably predictive.

Risk: 30-day mortality ~5% (sepsis most common)

Even in the PET-CT era, diagnostic splenectomy retains value — but strictly as a last-line diagnostic intervention.”

Title: Diagnostic Splenectomy: Clinical Profile, Role and Relevance in the Diagnosis of Lymphoma

Authors: Nutan Joshi, Sujith Karumathil, Sushil Selvarajan, Kavitha M. Lakshmi, S. Elanthenral, Santhosh Raj, Abi Manesh, Divya Susanna Ninan, Junita John, Myla Jacob, D. K. Titus, Uday Kulkarni, Biju George, Aby Abraham, Vikram Mathews, Anu Korula

Read the Full Article on Indian Journal of Hematology and Blood Transfusion.

John Abraham։ The Role of Diagnostic Splenectomy in Unexplained Splenomegaly

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Abi Manesh Aby Abraham Anu Korula Biju George D. K. Titus Divya Susanna Ninan Health Hematology Hemostasis News Hemostasis Today John Abraham Junita John Kavitha M. Lakshmi Medicine Myla Jacob Nutan Joshi S. Elanthenral Santhosh Raj Splenectomy splenomegaly Sujith Karumathil Sushil Selvarajan thrombosis Uday Kulkarni Vikram Mathews
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