Maha Othman: Uncovering the Consensus on TXA in TBI – Call for Collaboration on a Landmark Umbrella Review
Maha Othman, Co-Chairman SSC on Disseminated intravascular coagulopathy at International Society on Thrombosis and Haemostasis, shared a post on LinkedIn:
“Looking for an Umbrella Review expert to collaborate on a new manuscript on TXA and TBI
We are conducting an ‘Umbrella Review’ to evaluate the existing systematic reviews/meta-analyses, including their methodological quality, overlap in the primary RCTs, and where their conclusions agree or disagree.
We would like to answer this question:
‘What does the highest tier of evidence concluding in all systematic-reviews / clinical trials show about the efficacy and safety of TXA in TBI?
We would like to define where is the rock-solid consensus on TXA, and where the evidence remains muddy in this area.
Objectives: Compile all systematic reviews/ metanalyses on TXA in acute TBI (evaluating TXA dose/regimens, mortality, functional outcomes, and safety risks), critique review quality and quantify primary trial overlap and mapp out the exact reasons for conflicting conclusions in the literature.
This is being led by one of my brilliant mentees Drew Foster and is in collaboration with Dr. Gordon Boyd; critical care medicine specialist at Kingston Health Sciences Centre
If you have experience with umbrella review methodologies, CCA calculations, or AMSTAR 2 appraisals—and want to help shape a highly publishable piece of evidence synthesis, drop a comment below or send me a DM.”
Find more posts featuring Maha Othman on Hemostasis Today.
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