Ryan O’Keefe: Recognizing Warm AIHA From Hemolysis and a Positive DAT
Ryan O’Keefe, Internal Medicine Resident at the Hospital of The University of Pennsylvania, Creator of Point of Care Medicine, shared a post on X:
“Daily Pearl(s):
Warm Autoimmune Hemolytic Anemia (AIHA)
In warm AIHA, IgG antibodies bind to the surface of RBCs, which are then destroyed by macrophages in the spleen and liver via extravascular hemolysis.
Sepsis can be a non-malignant trigger of warm AIHA.
A rapid drop in Hgb with evidence of hemolysis (high LDH, low hapto) and a positive DAT is concerning for warm AIHA.
The presence of many nucleated RBCs (NRBCs) indicates bone marrow stress. NRBCs might be mistaken for WBCs by automated counters. This may inappropriately lead to concern for a leukemoid reaction.
Cephalosporins like CTX and cefepime are common causes of drug-induced immune hemolytic anemia.
Source: CPS – May 26, 2026 VMR with Ravi and Kirtan – new onset anemia.
Learn more clinical pearls from the Point of Care Medicine Substack!”
Stay updated with Hemostasis Today.
-
Oct 18, 2026, 02:43Priya Sriskandarajah: Diagnosis and Management of PV and JAK2-Unmutated Erythrocytosis
-
Oct 18, 2026, 02:41C. Michael Gibson: A Meta-Analysis of DOACs and DAPT After Left Atrial Appendage Closure
-
Oct 18, 2026, 02:27What Hematologists Should Remember About the Person Behind the Platelet Count – ASH
-
Oct 18, 2026, 01:44Marta Velia Antonini: How to Deliver CRRT during ECMO?
-
Oct 18, 2026, 01:19Aamir Saeed: Anticoagulation, Cirrhosis, and Other Risk Factors for Post-ERCP Bleeding
-
Oct 18, 2026, 00:33Elad Asher: Does Opening the Clot Change How a Patient Feels Three Months Later?
-
Oct 18, 2026, 00:22Richa Sharma: Evaluating Heterogeneity in Anticoagulation Treatment Effects in Cryptogenic Stroke
-
Oct 18, 2026, 00:07Irem Karaman Sebin: The Evidence Favoring Warfarin in High-Risk Antiphospholipid Syndrome
-
Oct 18, 2026, 00:07Emma Stevens: Lighting Up Buildings in Red and Blue for World Thrombosis Day