Dr. S.0 MIKAYE / LinkedIn
Apr 14, 2026, 14:48
Samwel Mikaye: From Virchow’s Triad to Prevention of PE in Patients with DVT
Samwel Mikaye, Medical Doctor at MSK, shared a post on LinkedIn:
“Deep vein thrombosis (DVT) is a condition where a blood clot forms in the deep veins, most commonly in the lower limb (calf or thigh).
It is dangerous because the clot can travel to the lungs and cause a pulmonary embolism.
Causes (Virchow’s triad)
DVT is mainly caused by three factors:
1. Venous stasis (slow blood flow)
- Long bed rest
- Prolonged travel (sitting for long hours
- Paralysis
2. Endothelial injury (vessel damage)
- Surgery
- Trauma
- IV catheters
3. Hypercoagulability (increased clotting tendency)
- Pregnancy
- Cancer
- Oral contraceptives
- Genetic clotting disorders
Symptoms
- Swelling of one leg (unilateral)
- Pain or tenderness in calf
- Warmth in affected leg
- Redness or discoloration
- Prominent veins
Dangerous complication
- Pulmonary embolism (clot moves to lungs)
- Sudden chest pain
- Shortness of breath
- Collapse (life-threatening)
Diagnosis
- Doppler ultrasound (first line)
- D-dimer test (screening)
- CT/MR venography (if needed)
Treatment
1. Anticoagulation (main treatment)
- Heparin (initial)
- Warfarin or DOACs (long-term)
2. Supportive care
- Leg elevation
- Pain relief
- Compression stockings
3. Severe cases
- Thrombolysis (clot dissolving drugs)
- Inferior vena cava (IVC) filter if anticoagulants cannot be used
Prevention
- Early mobilization after surgery
- Hydration
- Compression stockings
- Avoid long immobility
DVT is ‘Deep clot in leg leads to Danger to lungs.’ ”
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