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Zain Khalpey: The Path From Atherosclerosis to Heart Attack
Jun 2, 2026, 13:47

Zain Khalpey: The Path From Atherosclerosis to Heart Attack

Zain Khalpey, Adjunct Assistant Professor of Surgery at Columbia University Irving Medical Center, shared a post on LinkedIn:

Coronary artery disease is not always a sudden event.

In many patients, it develops gradually over years through progressive plaque formation, calcification, hemorrhage, thrombosis, and eventual vessel occlusion.

This pathology image captures the different stages of coronary narrowing and shows how blood flow can become critically reduced long before symptoms appear.

In some cases, plaque rupture and thrombosis can rapidly transform stable disease into an acute myocardial infarction.

Understanding the structural changes inside the coronary arteries is essential to understanding ischemia, infarction, and sudden cardiac events.”

Zain Khalpey: The Path From Atherosclerosis to Heart Attack

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