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Caitlin Raymond: When to Use Albumin vs. Plasma, and Why the Timing Matters
Caitlin Raymond/LinkedIn
Oct 7, 2025, 14:26

Caitlin Raymond: When to Use Albumin vs. Plasma, and Why the Timing Matters

 Caitlin Raymond, a board-certified Clinical Pathologist and current Transfusion Medicine Fellow at the National Institutes of Health, shared on LinkedIn:

“The Overlooked Half of the Exchange
When we talk about plasma exchange, most discussions stop at what we’re removing — antibodies, paraproteins, cytokines. But that’s only half the story.

Replacement fluid is the other half — and it quietly dictates safety, hemostasis, and recovery.

The right choice isn’t just technical; it’s clinical judgment in action.

In my latest blog post, I break down:

  • When to use albumin vs. plasma, and why the timing matters
  • How combination strategies (like 50:50 albumin–FFP) can balance practicality and bleeding risk
  • Common myths and misconceptions — including why “albumin is always safer” isn’t true
    Real-world scenarios: TTP, transplant desensitization, AMR, and more

Read the full post here.

Choosing the replacement fluid isn’t just following a protocol — it’s the art within the algorithm.

ecause in apheresis, the machines may be automated, but judgment isn’t.”

Caitlin Raymond: When to Use Albumin vs. Plasma, and Why the Timing Matters

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