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Dirk Sibbing on The Importance of ISAR-REACT 5 trial and 2020 ESC Guidelines for ACS
Dirk Sibbing/LinkedIn
Nov 5, 2025, 03:30

Dirk Sibbing on The Importance of ISAR-REACT 5 trial and 2020 ESC Guidelines for ACS

Dirk Sibbing, Professor, Cardiologist and Angiologist at Lauterbacher Mill Private Clinic and LMU Munich, shared on LinkedIn:

”Very impressive and important data published in EuroIntervention today, showing how impactful data from randomized trials can be…

In 2019, the randomized ISAR-REACT 5 trial demonstrated superiority of prasugrel over ticagrelor for treatment of ACS patients undergoing PCI

In consequence, the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation included a new COR IIa in preference for prasugrel for ACS-PCI

Then, an entire (!) country (Denmark) shifted treatment from routine use of ticagrelor over to prasugrel.

Results of this „real-life“ experiment are now published in Eurointervention

In 10,984 patients, prasugrel was associated with reduced 1-year rate of MACE (adjHR 0.67) and MI (adjHR 0.65), without differences in bleeding risk.

Risk reductions from randomized (ISAR-REACT 5) vs. observational data (Denmark) were very similar, thereby supporting current guideline recommendations

A great example for how impactful clinical trial data can be for the benefit of our patients.”

Read the full article here.

Article: Impact of shifting from routine use of ticagrelor to prasugrel in myocardial infarction patients after PCI: a nationwide cohort study

Authors: Mia Ravn Jacobsen, Peter Laursen Graversen, Reza Jabbari, Erik Lerkevang Grove, Charlotte Glinge, Lene Holmvang, Tobias Geisler, Lars Køber, Christian Torp-Pedersen, Thomas Engstrøm, Rikke Sørensen

Dirk Sibbing on The Importance of ISAR-REACT 5 trial and 2020 ESC Guidelines for ACS

Stay updated on all scientific advances in the field of thrombosis with Hemostasis Today.

ACS Charlotte Glinge Christian Torp-Pedersen COR IIa Dirk Sibbing Erik Lerkevang Grove ESC EuroIntervention Health Hematology Hemostasis Hemostasis Today ISAR-REACT 5 Lars Køber Lauterbacher Mill Private Clinic Lene Holmvang LMU Munich Medicine Mia Ravn Jacobsen PCI Peter Laursen Graversen prasugrel Reza Jabbari Rikke Sørensen Thomas Engstrøm thrombosis ticagrelor Tobias Geisler
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