Maria Pashayan Shares: Prognostic Implication of CYP2C19 Genotype
Maria Pashayan, Pharmacogenomics consultant at Center of Medical Genetics, posted on LinkedIn:
“In this large-scale, real-world analysis of DES-treated patients receiving clopidogrel-based dual antiplatelet therapy, high clinical risk (CHADS-P2A2RC ≥ 4 or TRS 2°P ≥ 3) was associated with worse clinical outcomes compared with low clinical risk.
Among clopidogrel-treated patients, carriage of the CYP2C19 LoF allele was linked to increased CV risk, particularly in those at high clinical risk. In low-risk patients, the prognostic relevance of the LoF allele carriage was mainly observed in those presenting with ACS.
Precision antiplatelet therapy works best when genetics + clinical risk + presentation (ACS vs CCS) are considered together—moving us closer to practical, evidence-based PGx implementation at the bedside.”
Title: Prognostic Implication of CYP2C19 Genotype According to Clinical Risk Stratification After Drug-Eluting Stent Implantation
Authors: Hyun Woong Park, Jae-Hwan Lee, Jin-Ok Jeong, Diana A. Gorog, Udaya S. Tantry, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Jin-Yong Hwang, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Woong Gil Choi, Jung Rae Cho, Jeehoon Kang, Sang Yeub Lee, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Paul A. Gurbel, Young-Hoon Jeong
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