Wolfgang Miesbach – ASH 2025: What’s Coming in Bleeding and Thrombosis?
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:
”By The Numbers
– 8,200 abstracts (record-breaking)
– 650-980 hemostasis-focused presentations across 8 categories
– 50 Sanofi abstracts | 46 Roche | 25+ Takeda contributions
– 6 late-breaking abstracts drop December 1 + 6 plenary abstracts
Haemophilia: Game-Changing Therapies
– Next-Gen Bispecific Antibodies
– Gene Therapy Updates
– RNA Silencing
Platelet Disorders: ITP Innovation
Rilzabrutinib (WAYRILZ) – First BTK inhibitor for ITP
– 65% platelet response vs 33% placebo
– 23% durable response vs 0% placebo
– Reduced bleeding + improved quality of life
– Plus: New data on rilzabrutinib in warm autoimmune hemolytic anemia (wAIHA) and sickle cell disease
Thrombosis: A Major Shift
NEW 2025 ASH/ISTH Pediatric VTE Guidelines
DOACs (rivaroxaban, dabigatran) now preferred over standard care (LMWH/warfarin) for kids with VTE. Oral anticoagulation changing the game.
Novel Thrombolytic Therapy
TargED Biopharmaceuticals’ TGD001 – first-in-human data on VWF-targeting thrombolytic for stroke, PE, and thrombotic thrombocytopenic purpura
Von Willebrand Disease
– VONVENDI Phase 3 pediatric data (supported Sept 2025 FDA approval)
– VGA039 – novel Protein S-targeting antibody with Phase 1/2 multidose results”
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