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HOPE Trial: Alteplase 4.5–24 Hours After Acute Ischemic Stroke
JAMA/X
Aug 8, 2025, 13:05

HOPE Trial: Alteplase 4.5–24 Hours After Acute Ischemic Stroke

JAMA shared an insightful post on X:

“In patients with salvageable brain tissue identified by perfusion imaging who did not initially receive thrombectomy, alteplase given 4.5 to 24 hours after acute ischemic stroke onset may improve functional outcomes.”

Read the full article here.

Title: Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours
The HOPE Randomized Clinical Trial

Authors: Ying Zhou, Yaode He, Bruce C. V. Campbell, David S. Liebeskind, Changzheng Yuan, Hui Chen, Yanxing Zhang, Tingyu Yi, Zhongyu Luo, Zuowen Zhang, Changcai Meng, Jianhua Cheng, Hezhong Ouyang, Jin Hu, Fei Wang, Sheng Zhang, Qi Fang, Haitao Hu, Xuting Zhang, Yi Chen, Wansi Zhong, Maarten G. Lansberg, Shenqiang Yan, Min Lou

Alteplase

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