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HOPE Trial: Alteplase 4.5–24 Hours After Acute Ischemic Stroke
JAMA/X
Aug 8, 2025, 13:05

HOPE Trial: Alteplase 4.5–24 Hours After Acute Ischemic Stroke

JAMA shared an insightful post on X:

“In patients with salvageable brain tissue identified by perfusion imaging who did not initially receive thrombectomy, alteplase given 4.5 to 24 hours after acute ischemic stroke onset may improve functional outcomes.”

Read the full article here.

Title: Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours
The HOPE Randomized Clinical Trial

Authors: Ying Zhou, Yaode He, Bruce C. V. Campbell, David S. Liebeskind, Changzheng Yuan, Hui Chen, Yanxing Zhang, Tingyu Yi, Zhongyu Luo, Zuowen Zhang, Changcai Meng, Jianhua Cheng, Hezhong Ouyang, Jin Hu, Fei Wang, Sheng Zhang, Qi Fang, Haitao Hu, Xuting Zhang, Yi Chen, Wansi Zhong, Maarten G. Lansberg, Shenqiang Yan, Min Lou

Alteplase

Stay informed with Hemostasis Today.

acute ischemic stroke Alteplase Bruce C. V. Campbell Changcai Meng Changzheng Yuan David S. Liebeskind Fei Wang Haitao Hu Health Hematology Hemostasis Hemostasis Today Hezhong Ouyang Hui Chen JAMA Jianhua Cheng Jin Hu Maarten G Lansberg Medicine Min Lou Qi Fang Sheng Zhang Shenqiang Yan stroke Thrombectomy Tingyu Yi Wansi Zhong Xuting Zhang Yanxing Zhang Yaode He Yi Chen Ying Zhou Zhongyu Luo Zuowen Zhang
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