Why TXA and rFVIIa Are Not Equivalent in Trauma Bleeding Control – RPTH Journal
RPTH Journal shared on LinkedIn about a recent article by Bilgimol Chumappumkal Joseph et al, adding:
”Tranexamic acid vs recombinant FVIIa in severe trauma: same goal, very different outcomes
Both tranexamic acid (TxA) and recombinant activated factor VII (rhFVIIa) can reduce bleeding in severe trauma.
But do they carry the same risks?
A new study in RPTH Journal puts them head-to-head in a murine liver laceration model.
Key findings:
- Both rhFVIIa and TxA reduced blood loss compared with controls
- TXA normalised coagulation parameters and suppressed fibrinolysis effectively
- Survival at 7 days: ~80% with TxA vs ~50% with rhFVIIa
- rhFVIIa overcorrected coagulation, failed to suppress D-dimer, and exacerbated IL-6 formation
- Pulmonary fibrin deposition and microthrombi were observed exclusively in rhFVIIa-treated mice.”
Title: The effects of recombinant human activated factor VII and tranexamic acid on traumatic bleeding and mortality in mice
Authors: Bilgimol Chumappumkal Joseph, Juan Andres De Pablo-Moreno, Nicca Falah, Abraham Wentzel, Mia Lora Cacho, Eduardo Frias-Anaya, Miguel Lopez-Ramirez, Annette von Drygalski
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