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Why TXA and rFVIIa Are Not Equivalent in Trauma Bleeding Control – RPTH Journal
RPTH Journal/LinkedIn
Apr 23, 2026, 05:32

Why TXA and rFVIIa Are Not Equivalent in Trauma Bleeding Control – RPTH Journal

RPTH Journal shared on LinkedIn about a recent article by Bilgimol Chumappumkal Joseph et al, adding:

”Tranexamic acid vs recombinant FVIIa in severe trauma: same goal, very different outcomes

Both tranexamic acid (TxA) and recombinant activated factor VII (rhFVIIa) can reduce bleeding in severe trauma.

But do they carry the same risks?

A new study in RPTH Journal puts them head-to-head in a murine liver laceration model.

Key findings:

  • Both rhFVIIa and TxA reduced blood loss compared with controls
  • TXA normalised coagulation parameters and suppressed fibrinolysis effectively
  • Survival at 7 days: ~80% with TxA vs ~50% with rhFVIIa
  • rhFVIIa overcorrected coagulation, failed to suppress D-dimer, and exacerbated IL-6 formation
  • Pulmonary fibrin deposition and microthrombi were observed exclusively in rhFVIIa-treated mice.”

Title: The effects of recombinant human activated factor VII and tranexamic acid on traumatic bleeding and mortality in mice

Authors: Bilgimol Chumappumkal Joseph, Juan Andres De Pablo-Moreno, Nicca Falah, Abraham Wentzel, Mia Lora Cacho, Eduardo Frias-Anaya, Miguel Lopez-Ramirez, Annette von Drygalski

Why TXA and rFVIIa Are Not Equivalent in Trauma Bleeding Control - RPTH Journal

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Abraham Wentzel Annette von Drygalski Bilgimol Chumappumkal Joseph bleeding disorders blood loss Eduardo Frias-Anaya FVIIa Health Hematology Hemostasis Hemostasis News Hemostasis Today Juan Andrés De Pablo Moreno Medicine Mia Lora Cacho Miguel Lopez-Ramirez Nicca Falah rpth tranexamic acid
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