Brianne D.: Sex Differences in RIPK1 Signaling Following Intracerebral Hemorrhage
Brianne D., Research Technician II at Mass Geneal Brigham, shared a post on LinkedIn about a recent article by Hongmei Yang et al, published in Journal of Cerebral Blood Flow and Metabolism, adding:
“Excited to share a new publication where our findings reveal important sex differences in RIPK1 signaling after intracerebral hemorrhage (ICH) and highlight the need to consider sex when developing RIPK1-targeted treatments and conducting future brain injury research.
We found that thirty-five days after intracerebral hemorrhage (ICH), RIPK1 activation in male mice was observed in various cell types, where it contributed to neuronal damage, inflammation, blood-brain barrier (BBB) disruption, and cognitive deficits. Whereas in females, RIPK1 activation occurred exclusively in neurons and did not produce the same biochemical changes or significantly regulate most injury-related outcomes that were observed in males.”
Title: EXPRESS: Sex-dependent roles for RIPK1 in the subacute period of intracerebral hemorrhage in mice
Authors: Hongmei Yang, Brianne Elise Dillon, Dalila Mary Marzialo, Jaina Therese Dillon, Tian Cao, Emily S Levy, Lindsay Popeo, Shirin Jamali, David Wootton, Eva Grzegorczyk, Cameron Marie Beckey, Amir Davis, Nandita Karthik, Paige Ingrando, Riley L Stogsdill, Binh Minh Ngoc Nguyen, Ruxandra F Sirbulescu, Alexei Degterev, Michael J Whalen, Limin Wu
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