Chokri Ben Lamine: PNH beyond the Textbook Triad
Chokri Ben Lamine, Hematologist at King Faisal Specialist Hospital and Research Center, shared a post on X:
“PNH beyond the textbook triad
Key takeaways from Dr. Mohammed Almakadi, KFSH Almadinah, at SOHO KSA 2026.
Unexplained hemolysis, disproportionate anemia or atypical thrombosis in a myeloid neoplasm should prompt consideration of PNH testing.
Use high-sensitivity FLAER-based flow cytometry with lineage-specific clone quantification.
PNH can coexist with MPN or CML. Distinguish clinically significant disease from an incidental clone.
Integrate hemolysis, symptoms, thrombosis and clonal context. Clone detection alone does not justify complement inhibition.
Treat the patient, monitor the clone, and target complement when clinically indicated.”
Title 1: PNH clones prevalence study in ph-negative myeloproliferative neoplasms: a multicenter Italian study
Authors: Alessandra D’Addio, Michela Rondoni, Marzia Salvucci, Giovanni Marconi, Massimiliano Bonifacio, Ilaria Tanasi, Omar Perbellini, Giuseppe Carli, Patrizia Tosi, Simona Tomassetti, Giovanni Poletti, Evita Massari, Marco Rosetti, Elisabetta Fabbri, Chiara Zingaretti, Alessandro Lucchesi, Maria Teresa Bochicchio, Giorgia Simonetti, Mauro Krampera, Francesco Lanza
Read the Full Article on Annals of hematology
Title 2: When does a PNH clone have clinical significance?
Authors: Daria V Babushok
Read the Full Article on Hematology. American Society of Hematology. Education Program
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