Christoph B. Olivier: What If We Reduce Cardiovascular Collapse in PE by 60% Without Increasing Bleeding?
Christoph B. Olivier, Head of the Clinical Trials Unit, UHZ Freiburg, shared on LinkedIn about a recent article by Kenneth Rosenfield et al, published in NEJM:
”HI-PEITHO Results in the NEJM Group
What if we could reduce the risk of cardiovascular collapse in pulmonary embolism patients by more than 60% without increasing major bleeding?
Publication of the HI-PEITHO trial led by Stavros V. Konstantinides and Kenneth Rosenfield in NEJM.
Key Findings: In 544 patients with intermediate-risk PE, ultrasound-facilitated, catheter-directed fibrinolysis significantly outperformed anticoagulation alone.
60% Risk Reduction: We saw a major drop in life-threatening complications and death (down to 4.0% from 10.3%).
Safety: No significant increase in major bleeding or intracranial hemorrhage.
This study, funded by Boston Scientific, proves that a precision-driven, catheter-based approach can prevent cardiorespiratory decompensation.”
Title: Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism
Authors: Kenneth Rosenfield, Frederikus Klok, Gregory Piazza, Andrew Sharp, Fionnuala Ní Áinle, Michael Jaff, Stefano Barco, Samuel Goldhaber, Nils Kucher, Irene Lang, Irene Schmidtmann, Keith Sterling, Aleksander Araszkiewicz, Vishal Arora, Rafael Cires-Drouet, John Coghlan, Lukas Hobohm, Wulf Ito, Kurt Jacobson, Christoph Kaiser, Grzegorz Kopec, Kristin Marx, Samuel McElwee, Nicolas Meneveau, Peter Monteleone, Jose Montero-Cabezas, Christoph Olivier, John Park, Marek Roik, Rahul Sakhuja, Andi Tego, Markus Theurl, Gautam Visveswaran, Jan Vos, Michael Young, Federico Asch, Stavros Konstantinides for the HI-PEITHO Investigators
Read the Full Article on NEJM
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