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Christoph B. Olivier: What If We Reduce Cardiovascular Collapse in PE by 60% Without Increasing Bleeding?
Christoph B. Olivier/LinkedIn
Mar 29, 2026, 06:11

Christoph B. Olivier: What If We Reduce Cardiovascular Collapse in PE by 60% Without Increasing Bleeding?

Christoph B. Olivier, Head of the Clinical Trials Unit, UHZ Freiburg, shared on LinkedIn about a recent article by Kenneth Rosenfield et al, published in NEJM:

”HI-PEITHO Results in the NEJM Group

What if we could reduce the risk of cardiovascular collapse in pulmonary embolism patients by more than 60% without increasing major bleeding?

Publication of the HI-PEITHO trial led by Stavros V. Konstantinides and Kenneth Rosenfield in NEJM.

Key Findings: In 544 patients with intermediate-risk PE, ultrasound-facilitated, catheter-directed fibrinolysis significantly outperformed anticoagulation alone.

60% Risk Reduction: We saw a major drop in life-threatening complications and death (down to 4.0% from 10.3%).

Safety: No significant increase in major bleeding or intracranial hemorrhage.

This study, funded by Boston Scientific, proves that a precision-driven, catheter-based approach can prevent cardiorespiratory decompensation.”

Title: Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism

Authors: Kenneth Rosenfield, Frederikus Klok, Gregory Piazza, Andrew Sharp, Fionnuala Ní Áinle, Michael Jaff, Stefano Barco, Samuel Goldhaber, Nils Kucher, Irene Lang, Irene Schmidtmann, Keith Sterling, Aleksander Araszkiewicz, Vishal Arora, Rafael Cires-Drouet, John Coghlan, Lukas Hobohm, Wulf Ito, Kurt Jacobson, Christoph Kaiser, Grzegorz Kopec, Kristin Marx, Samuel McElwee, Nicolas Meneveau, Peter Monteleone, Jose Montero-Cabezas, Christoph Olivier, John Park, Marek Roik, Rahul Sakhuja, Andi Tego, Markus Theurl, Gautam Visveswaran, Jan Vos, Michael Young, Federico Asch, Stavros Konstantinides for the HI-PEITHO Investigators

Read the Full Article on NEJM

Christoph B. Olivier: What If We Reduce Cardiovascular Collapse in PE by 60% Without Increasing Bleeding?

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Aleksander Araszkiewicz Andi Tego Andrew Sharp Christoph B. Olivier Christoph Kaiser Christoph Olivier DVT Federico Asch Fionnuala Ní Áinle Frederikus Klok Gautam Visveswaran Gregory Piazza Grzegorz Kopec Health Hematology Hemostasis Hemostasis News Hemostasis Today HI-PEITHO Irene Lang Irene Schmidtmann Jan Vos John Coghlan John Park Jose Montero-Cabezas Keith Sterling Kenneth Rosenfield Kristin Marx Kurt Jacobson Lukas Hobohm Marek Roik Markus Theurl Medicine Michael Jaff Michael Young NEJM Nicolas Meneveau Nils Kucher PE Peter Monteleone Rafael Cires-Drouet Rahul Sakhuja Samuel Goldhaber Samuel McElwee Stavros Konstantinides Stefano Barco thrombosis Vishal Arora VTE Wulf Ito
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