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Daniel Soffer: ApoA-1 vs HDL-C as Markers of Cardiovascular Risk
Daniel Soffer/LinkedIn, Pablo Corral/LinkedIn
May 19, 2026, 15:51

Daniel Soffer: ApoA-1 vs HDL-C as Markers of Cardiovascular Risk

Pablo Corral Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared a post on LinkedIn about a recent article by Selin Bilgic et al., published in Journal of Clinical Lipidology, adding:

“ApoA-1 versus HDL-C as markers of cardiovascular risk

HDL-C or ApoA-1:which better reflects cardiovascular risk?

A new analysis from nearly 300,000 UK Biobank participants revisits one of the oldest debates in lipidology:

Key findings:

  • ApoA-1 and HDL-C showed similarly strong inverse associations with ASCVD risk
  • ApoA-1 explained most of the protective signal traditionally attributed to HDL-C
  • Triglycerides contributed far less than expected
  • HDL biology may still matter more than many currently assume

Interesting message from this paper:

The story of HDL is probably more nuanced than simply saying ‘HDL is not causal.’

Negative HDL-raising trials did not kill the biology.

They only killed simplistic pharmacology.”

 

Daniel soffer, Associate Professor of Medicine at University of Pennsylvania, shared this post on LinkedIn:

“Pablo Corral, as usual your posts and commentary are brilliant.

Clearly, HDL is important and clearly, we are measuring what it does poorly.

Manipulating its cholesterol content in serum and even how many HDL particles are in circulation is not the secret.

Perhaps we will figure out how to manipulate HDL for good one day beyond eating healthy, exercising regularly, managing sleep and stress.”

Title: ApoA-1 versus HDL-C as markers of cardiovascular risk

Authors: Selin Bilgic, Karol Pencina, Michael Pencina, Line Dufresne, George Thanassoulis, Allan Sniderman

Daniel Soffer

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Allan Sniderman Daniel Soffer George Thanassoulis Health Hematology Hemostasis Hemostasis News Hemostasis Today Karol Pencina Line Dufresne Medicine Michael Pencina Pablo Corral Selin Bilgic
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