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Danny Hsu: The Diagnostic Challenge of Pulmonary Embolism During Pregnancy
Danny Hsu/LinkedIn
Feb 14, 2026, 14:34

Danny Hsu: The Diagnostic Challenge of Pulmonary Embolism During Pregnancy

Danny Hsu, President of THANZ, shared RPTH Journal’s post on LinkedIn, adding:

“Excellent article on the challenging scenario of diagnosing PE in pregnancy!”

RPTH Journal shared a post on LinkedIn, about a recent article by Fanny Collange et al, adding: :

“Diagnosing pulmonary embolism in pregnancy is still harder than we think.

We rely heavily on clinical probability scores like Wells and Geneva, but do they actually work in pregnant women with prior VTE?

A new Highlow ancillary study puts this to the test in 1,110 high-risk pregnancies.

The results are eye-opening

Among 102 suspected PE cases:

  • Only 12 were confirmed
  • Incidence during pregnancy: 2.6% of suspected cases
  • Postpartum: 42% of suspected cases

Now the key finding:

Wells, Geneva, and pregnancy-adapted Geneva scores all showed modest discriminatory power

Translation:

These tools struggle in the exact population where we need them most.

Why?

Because pregnancy changes physiology, symptoms overlap with normal pregnancy, and prior VTE history dominates risk assessment.

Big takeaway:

We urgently need pregnancy-specific PE decision tools to safely reduce imaging and radiation exposure.

This study highlights a major unmet need in maternal thrombosis care.”

Title: Assessment of clinical probability scores for pulmonary embolism diagnosis during pregnancy and postpartum in women with a history of venous thromboembolism: a Highlow ancillary study

Authors: Fanny Collange, Ingrid M Bistervels, Andrea Buchmuller, Hanke MG Wiegers, Fionnuala Ní Áinle, Peter Verhamme, Anne F Jacobsen, Anette T Hansen, Marc A Rodger, Maria T DeSancho, Roman G Shmakov, Luuk JJ Scheres, Celine Chauleur, Saskia Middeldorp, Bernard Tardy

Read the Full Article on RPTH Journal.

Danny Hsu: The Diagnostic Challenge of Pulmonary Embolism During Pregnancy

Find more posts  featuring Danny Hsu on Hemostasis Today.

Andrea Buchmuller Anette T Hansen Anne F Jacobsen Bernard Tardy bleeding disorders Celine Chauleur Danny Hsu Fanny Collange Fionnuala Ní Áinle Hanke MG Wiegers Headlines Health Hematology Hemostasis News Hemostasis Today Ingrid M Bistervels Luuk JJ Scheres Marc A Rodger Maria T DeSancho Medicine PE Peter Verhamme Pregnancy Pulmonary embolism Roman G Shmakov RPTH Journal Saskia Middeldorp thrombosis VTE
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