Filippo Consonni: Treatment Strategies for Hematologic Immune Dysregulation in Inborn Errors of Immunity
Filippo Consonni, Assistant Professor of Pediatrics (RTD-A), MD/PhD Candidate in Biomedical Sciences, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Frontiers in Immunology, adding:
“Finally out!
Glad to share our new multicenter Italian study on the treatment of hematologic immune dysregulation in patients with inborn errors of immunity (IEI), now published in Frontiers in Immunology.
Hematologic manifestations – including autoimmune cytopenias, lymphoproliferation, and HLH – are among the most frequent and potentially life-threatening complications of IEI.
However, the optimal therapeutic strategies remain far from well established.
In this multicenter retrospective cohort of 116 patients from Italian tertiary referral centers, we evaluated real-world treatment indications, efficacy, and safety across conventional, targeted, and transplant-based approaches.
Our findings highlight the remarkable efficacy of targeted therapies, which achieved significantly higher response rates than non-targeted treatments, while also underscoring the persistent heterogeneity in treatment decisions and the need for broader access to molecular diagnosis to enable precision medicine.
A sincere thank you to Giorgio Costagliola and the Società Italiana di Ricerca Pediatrica (SIRP) for coordinating this collaborative project, and to all co-authors and participating centers for their invaluable contribution.”
Title: Treating hematologic immune dysregulation in inborn errors of immunity: a real-life multicenter study
Authors: Giorgio Costagliola, Filippo Consonni, Riccardo Castagnoli, Mayla Sgrulletti, Eleonora Gambineri, Giuliana Giardino, Federica Cavone, Davide Montin, Francesca Conti, Baldassarre Martire, Matteo Chinello, Irene D’Alba, Francesco Saettini, Adele Civino, Gian Luigi Marseglia, Roberta Romano, Beatrice Rivalta, Fabiola Guerra, Emilia Cirillo, Lucia Pacillo, Francesca Cillo, Laura Grilli, Federico Diomeda, Mattia Moratti, Francesca Robasto, Caterina Cancrini, Gabriella Casazza, Claudio Pignata, Viviana Moschese, Rita Consolini
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