Giulia Simini: Acquired von Willebrand Syndrome and Coagulation Abnormalities in MPN-Associated Thrombocytosis
Giulia Simini, Resident doctor in Hematology at NHS England, shared a post on LinkedIn about a recent article she and her colleagues co-authored, adding:
“Just published on RPTH!
Acquired von Willebrand syndrome is a often underdiagnosed and misdiagnosed complication of MPNs.
In this cohort of MPN patients with thrombocytosis, 33 percent developed bleeding complications.
However, platelets count alone was not a predictor of bleeding risk.
Interestingly, we found a significant correlation between vWF:RCo/Ag ratio and PT, as well as APTT.
This potentially suggests other coagulation imbalances in patients with MPNs.
One patient was found to have FV deficiency and dysfibrinogenemia.
A tailored approach is essential to assess bleeding risk in this cohort.”
Title: Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center
Authors: Giulia Simini, Andrew Innes, Saravanan Vinayagam, Golzar Mobayen, Nilanthi Karawitage, Simone Claudiani, Zain Odho, Mike Laffan, Deepa J. Arachchillage
Read the Full Article on RPTH.
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