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Giulia Simini: Acquired von Willebrand Syndrome and Coagulation Abnormalities in MPN-Associated Thrombocytosis
Giulia Simini/LinkedIn
Apr 8, 2026, 07:32

Giulia Simini: Acquired von Willebrand Syndrome and Coagulation Abnormalities in MPN-Associated Thrombocytosis

Giulia Simini, Resident doctor in Hematology at NHS England, shared a post on LinkedIn about a recent article she and her colleagues co-authored, adding:

“Just published on RPTH!

Acquired von Willebrand syndrome is a often underdiagnosed and misdiagnosed complication of MPNs.

In this cohort of MPN patients with thrombocytosis, 33 percent developed bleeding complications.

However, platelets count alone was not a predictor of bleeding risk.

Interestingly, we found a significant correlation between vWF:RCo/Ag ratio and PT, as well as APTT.

This potentially suggests other coagulation imbalances in patients with MPNs.

One patient was found to have FV deficiency and dysfibrinogenemia.

A tailored approach is essential to assess bleeding risk in this cohort.”

Title: Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center

Authors: Giulia Simini, Andrew Innes, Saravanan Vinayagam, Golzar Mobayen, Nilanthi Karawitage, Simone Claudiani, Zain Odho, Mike Laffan, Deepa J. Arachchillage

Read the Full Article on RPTH.

Giulia Simini: Acquired von Willebrand Syndrome and Coagulation Abnormalities in MPN-Associated Thrombocytosis

Other posts featuring Giulia Simini on Hemostasis Today.

Andrew Innes aPTT Deepa J. Arachchillage Giulia Simini Golzar Mobayen Health Hematology Hemostasis News Hemostasis Today Medicine Mike Laffan myeloproliferative neoplasms Nilanthi Karawitage rpth Saravanan Vinayagam Simone Claudiani Thrombocytosis Von Willebrand Zain Odho
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