Archil Jaliashvili: Novel Rescue in Hyperhaemolysis Syndrome of Sickle Cell Anaemia
Archil Jaliashvili, Co-owner, General Manager of SkinAI, Co-Chief Executive Officer at GeoBio Pharm, shared on LinkedIn:
‘‘Novel Rescue in Hyperhaemolysis Syndrome of Sickle Cell Anaemia (SCA)
Hyperhaemolysis syndrome (HHS) remains one of the most fatal complicatios of transfusion in SCA, with rapid destruction of both transfused and autologous RBCs.
Conventional therapies (steroids, IVIG, rituximab, eculizumab) often fail, leaving clinicians with limited options.
Case (Epstein and Hadley, J Clin Pharm Ther)
• 19-year-old male with SCA developed HHS post partial exchange transfusion.
• Hb fell to 4.0 g/dL despite methylprednisolone, darbepoetin, rituximab.
• Severe hemoglobinuria, LDH 7,120 U/L, Coombs negative.
New oxygenation therapeutic Breakthrough:
Hemopure (BHOC – our new gen bio analog)
• Single infusion restored oxygen delivery instantly.
• Clinically, the patient regained energy and responsiveness despite critical Hb.
• Effect lasted ~5 hours.
Bortezomib (26S proteasome inhibitor)
• 1.3 mg/m² SC q72h × 4 doses.
• Downregulated NF-κB–driven macrophage activation and hemolysis.
• Hb rose from 4.0 → 7.0 g/dL, reticulocyte count >20%.
Outcome: Patient stabilized and discharged. No alloantibodies detected later.
Why important:
•Hemopure has demonstrated value as a bridge oxygen carrier when hemoglobin (Hb) levels are critically low.
• Bortezomib represents a novel immune-modulating option in transfusion-refractory hyperhemolytic syndromes (HHS).
• This case supports the expansion of HBOCs in clinical emergencies and the initiation of clinical trials of proteasome inhibitors in hemolytic syndromes.
About future possibility:
Our next-generation bio-similar BHOC can serve as a bridge to recovery.
We believe it can transform the approach to Sickle Cell Anemia (SCA) treatment by providing supportive, low-volume infusion therapy before HbS levels become critical.
Much like insulin regulates blood sugar and HbA1c levels, BHOC can help support and control HbS polymerization level, stabilizing oxygen delivery and patient condition.
Contact us for collaboration or discussion about clinical applications and partnerships.”
Article: Successful management of potentially fatal hyperhaemolysis syndrome of sickle cell anaemia with a regimen including bortezomib and Hemopure
Authors: Stacy S. Epstein, Terence J. Hadley
Stay updated with all science in the field of hematology with Hemostasis Today.
-
Oct 19, 2025, 06:11Soumya Sayujya: A Routine Lab, An Incidental Finding, And a Lesson I Won’t Forget
-
Oct 19, 2025, 04:29Peter Mezes Thanks Thrombosis UK and North Bristol NHS Trust for The Support
-
Oct 19, 2025, 04:02Salvador Payán Pernía Highlights PIGA Gene Case and Thalassemia Advances at 5th Rare Diseases Conference in Hematology
-
Oct 18, 2025, 16:59Raul Santos Gave 2 Talks at SAC 2025: On The Role of LDL-C and Future of Lipid-lowering Therapies
-
Oct 18, 2025, 16:57Marilena Vrana: What An Inspiring Week at The 2025 Plasma Protein Forum and Business Forum
-
Oct 19, 2025, 04:59Nazim Arain Shares The New Standard: Anticoagulation in Cirrhosis
-
Oct 19, 2025, 04:43Andrea Zini on Atrial Fibrillation Detection After Acute Ischemic Stroke
-
Oct 19, 2025, 03:43Ibrahim Antoun Describes LV Thrombus of Unknown Origin in Apical HCM
-
Oct 18, 2025, 16:56Alexandra Whiteside on Improving Coagulation Kinetics
-
Oct 18, 2025, 16:52Wolfgang Miesbach on Differential Diagnosis of Thrombocytopenia
-
Oct 16, 2025, 06:07ClearPlasma - A New Breakthrough in Stopping Life-Threatening Bleeds
-
Oct 14, 2025, 05:26Ryan C. Heniford: Every Thrombus Prevented Is a Patient Protected
-
Oct 13, 2025, 04:48Archil Jaliashvili showcases how BHOC builds on Hemopure’s success to revolutionize surgery and care
-
Oct 13, 2025, 02:46Flora Peyvandi: First Proposed Blood Test for Chronic Fatigue Syndrome - What Scientists Think
-
Oct 13, 2025, 02:44Silvio Maresca: Honored to be part of this international research project - ThrombUS+
-
Oct 19, 2025, 04:14Sue Bacon: Ensure That You and Your Loved Ones Are Aware of The Signs and Symptoms of DVT And PE
-
Oct 19, 2025, 03:52Yazan Abou Ismail Receives The Qatar Foundation Legacy Award
-
Oct 18, 2025, 16:55Emilia Arturo: Your Reminder to Donate Blood If You Can, When You Can
-
Oct 18, 2025, 16:51Allison Wheeler Rallies Support for Magdalena Lewandowska's NYC Marathon Run Benefiting NBDF
-
Oct 18, 2025, 05:19Shashi Prakash: Test Your Clotting Concepts!