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Genetic Insights: FVIII A3 Variants and Inhibitor Risk
Aug 18, 2025, 09:03

Genetic Insights: FVIII A3 Variants and Inhibitor Risk

Flora Peyvandi, Professor of Internal Medicine-Hemostasis and Thrombosis Unit, University of Milan, former President of ISTH, shared on X:

”Deleterious variants cluster in the A3 domain of factor VIII in severe patients with haemophilia A and inhibitors – the role of F8 genotype and specific FVIII domains in inhibitor development in an admixed population of PwHA.”

Read the full article here.

Article: Deleterious variants cluster in the A3 domain of factor VIII in severe patients with haemophilia A and inhibitors

Authors: Luciana Werneck Zuccherato, Renan Pedra Souza, Ricardo Mesquita Camelo, Márcio Antônio Portugal Santana, Maíse Moreira Dias, Letícia Lemos Jardim, Andrea Gonçalves de Oliveira, Claudia Santos Lorenzato, Monica Hermida Cerqueira, Vivian Karla Brognoli Franco, Rosangela de Albuquerque Ribeiro, Leina Yukari Etto, Maria do Rosario Ferraz Roberti, Fábia Michelle Rodrigues de Araújo Callado, Maria Aline Ferreira de Cerqueira, Ieda Solange de Souza Pinto, Andrea Aparecida Garcia, Tania Hissa Anegawa, Daniele Campos Fontes Neves, Daniel Gonçalves Chaves, Suely Meireles Rezende, [email protected] on behalf of the HEMFIL and the Brazilian Immune Tolerance (BrazIT) Study

Inhibitor

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A3 domain Andrea Aparecida Garcia Andrea Gonçalves de Oliveira Brazilian Immune Tolerance (BrazIT) Study Claudia Santos Lorenzato Daniel Gonçalves Chaves Daniele Campos Fontes Neves Fábia Michelle Rodrigues de Araújo Callado Factor VIII Factor VIII Inhibitors Flora Peyvandi haemophilia A Health Hematology HEMFIL Hemophilia A Hemophilia with Inhibitors Hemostasis Today Ieda Solange de Souza Pinto Leina Yukari Etto Letícia Lemos Jardim Luciana Werneck Zuccherato Maíse Moreira Dias Márcio Antônio Portugal Santana Maria Aline Ferreira de Cerqueira Maria do Rosario Ferraz Roberti Medicine Monica Hermida Cerqueira PwHA Renan Pedra Souza Ricardo Mesquita Camelo Rosangela de Albuquerque Ribeiro Suely Meireles Rezende Tania Hissa Anegawa Vivian Karla Brognoli Franco
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