Marc Carrier: TRIM-Line Trial Evaluates VTE Prevention in Cancer
Marc Carrier, Professor at Ottawa Hospital Research Institute, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Thrombosis and Haemostasis, adding:
“An important knowledge gap: patients with cancer and a central venous catheter face an increased risk of venous thromboembolism, yet definitive evidence to support routine thromboprophylaxis after catheter insertion is lacking.
TRIM-Line is an ongoing randomized trial comparing rivaroxaban 10 mg daily with placebo for 90 days to determine whether prophylaxis reduces VTE with an acceptable bleeding risk.
We have enrolled 500 Canadian patients!
We are planning to open sites in France, Saudi Arabia and Italy.”
Title: Primary Thromboprophylaxis in Patients with Malignancy and Central Venous Catheters: TRIM-Line Randomized Controlled Trial—Design and Rationale
Authors: Tzu-Fei Wang, Rick Ikesaka, Isabelle Mahé, Danny Hill, Catherine Sperlich, Vicky Tagalakis, Sudeep Shivakumar, Blair Leonard, Andrea Cervi, Philip G. Kuruvilla, Fréderic Larose, Davide Matino, Steffan Frosi Stella, Chantal Séguin, Abdulrahman Al Raizah, Grégoire Le Gal, Deborah M. Siegal, Aurélien Delluc, Ranjeeta Mallick, Alejandro Lazo-Langner, Cynthia Wu, Dennis Christopher, Marcello Di Nisio, Walter Ageno, Bashour Yazji, Marc Carrier
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