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Marloes de Kovel: FVIII Exposure With Severe Haemophilia A on Emicizumab Prophylaxis
Marloes de Kovel/ LinkedIn
Aug 25, 2026, 12:10

Marloes de Kovel: FVIII Exposure With Severe Haemophilia A on Emicizumab Prophylaxis

Marloes de Kovel, Epidemiologist and Research Coordinator at PedNet Haemophilia Research Foundation, shared a Journal of Thrombosis and Haemostasis‘s post on LinkedIn about a recent article she and her colleagues co-authored, adding:

“Delighted to share our brief report on FVIII exposure, bleeding outcomes, and inhibitor development in PUPs and MTPs with severe haemophilia A on emicizumab prophylaxis.”

Journal of Thrombosis and Haemostasis shared a post on LinkedIn:

“FVIII exposure, bleeding outcomes, and inhibitor development in 80 PUPs and MTPs with severe hemophilia A on emicizumab prophylaxis: real-world data from the PedNet Registry

Real-world data on emicizumab in infants with severe hemophilia A remain thin beyond HAVEN 7.

Across 80 previously or minimally treated infants in the PedNet Registry, first FVIII exposure was delayed and bleeding control was good, with a mean annualized bleeding rate of 0.6.

Five developed inhibitors, and preliminary analysis suggested no drop in inhibitor development. No thrombosis occurred.”

Title: Factor VIII exposure, bleeding outcomes, and inhibitor development in 80 previously untreated patients and minimally treated patients with severe hemophilia A on emicizumab prophylaxis: real-world data from the PedNet Registry

Authors: Marloes de Kovel, Gili Kenet, Jayashree Motwani, Nadine G. Andersson, Jan Blatný, Giancarlo Castaman, Manuel Carcao, Carmen Escuriola Ettingshausen, Christoph Königs, Christoph Male, Beatrice Nolan, Martin Olivieri, Caroline Oudot, Helen Pergantou,  Susanna Ranta,  Ester Zapotocka, Kathelijn Fischer

Marloes de Kovel: FVIII Exposure With Severe Haemophilia A on Emicizumab Prophylaxis

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Beatrice Nolan Carmen Escuriola Ettingshausen Caroline Oudot Christoph Königs Christoph Male Ester Zapotocka Giancarlo Castaman Gili Kenet Health Helen Pergantou Hematology Hemostasis Hemostasis News Hemostasis Today Jan Blatný Jayashree Motwani Kathelijn Fischer Manuel Carcao Marloes de Kovel Martin Olivieri Medicine Nadine G. Andersson Susanna Ranta
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