Mary Cushman: What Causes PE to Happen in People with DVT?
Mary Cushman, University Distinguished Professor and Vice Chair at the University of Vermont, shared a post on LinkedIn, about a recent article she and her colleagues co-authored, published in Journal of Thrombosis and Haemostasis, adding:
“This was a fun paper to help out with!
What causes PE to happen in people with DVT?
We used genomics and transcriptomics to identify factors related to this.
F5 rs6025 – factor V Leiden was associated with lower risk.
We already knew this.
FVL may lead to more stable clots.
Common variants in the FGG and the F11 genes associated with VTE related to increased risk.
Maybe because of bigger thrombi or weaker or less stable thrombi.
SLC12A2-DT associated with lower risk.
Maybe through red cell mechanism
CDHR4 transcripts associated with increased risk. Might relate to cell-cell adhesion mechanism.
The overall effect of these associations was modest but could these biologies be prevention targets?”
Title: Genetic associations with pulmonary embolism among those with a deep vein thrombosis: The Invent Consortium
Authors: Susana Lozano-Esparza, Gabrielle E. Shakt, Jennifer A. Brody, Angel Martinez-Perez, Matthew P. Conomos, Marine Germain, Katharine R. Clapham, Maris Teder-Laving, Astrid van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C.L. Bezerra, Girish Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L. Goode, Yuekai Ji, Daniel I. Chasman, Alexander P. Reiner, Constance Turman, Kerri L. Wiggins, Colleen M. Sitlani, Juan Carlos Souto, Pamela L. Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, FinnGen, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M. Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwi, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S. Pankow, Paul M. Ridker, Yuxi Liu, Ken M. Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M. Psaty, Pradeep Natarajan, Andrew D. Johnson, Marc A. Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S. Wolberg, Scott M. Damrauer, Nicholas L. Smith
Other posts featuring Mary Cushman on Hemostasis Today.
-
Oct 5, 2026, 15:31Irma Bagdoniene: Multidisciplinary Management of High-Risk Familial Hypercholesterolaemia and CAD
-
Oct 5, 2026, 15:00Serena Williams and Pulmonary Embolism: From Personal Crisis to Lessons in Venous Thromboembolism
-
Oct 5, 2026, 14:55Marco Moscarelli: 3D Reconstruction Enhances Volumetric Assessment of Post-TAVI Thrombosis
-
Oct 5, 2026, 13:24Abdul Muqtadir Abbasi: Diagnostic Pearls for Evaluating Isolated Thrombocytopenia in Residents
-
Oct 5, 2026, 13:16Katerina Pavenski: Rethinking What ‘Normal’ Means for Iron Deficiency
-
Oct 5, 2026, 13:09Rick Matthews: Balancing Established VTE Partnerships with Innovative Interventional Technologies
-
Oct 5, 2026, 13:01Nawsherwan Mohammad: Recognizing TTP Before the ADAMTS13 Result Arrives
-
Oct 5, 2026, 12:51Bruno Pougault: The Hidden Challenges Behind Anti Xa Testing
-
Oct 5, 2026, 12:41Syed Huzaifa Khan: Rethinking CTRP12 as a Biomarker for In Stent Restenosis