Melanie Daniel: Modeling High-Purity von Willebrand Factor for Individualized Dosing in Surgery
Melanie Daniel, Physician at Lille University Hospital, shared Inserm UMR 1011 – Hemostasis and Cardiovascular Flow’s post on LinkedIn adding:
”Very happy to see our work on VWF pharmokinetics in surgery now published in Blood Advances.
In this study, we developed a population PK/PD model of high-purity von Willebrand factor to better understand treatment response and variability during surgery in patients with von Willebrand disease, highlighting the need for more individualized dosing strategies.
Nearly 100 years after Erik von Willebrand first described the disease in 1926, we are still working to better understand and optimize its management.
We are especially grateful to the patients who contributed to this research, and to the many collaborators across Lille, Saint-Étienne and the HITh lab Inserm in Paris, alongside Prof Sophie Susen and Prof Xavier Delavenne.”
Inserm UMR 1011 – Hemostasis and Cardiovascular Flow shared a post on LinkedIn about a recent article by Melanie Daniel et al, published in Blood Advances:
”New publication in Blood Advances
How can we better tailor treatment for patients with von Willebrand disease undergoing surgery?
In this study, we developed a population PK/PD model of high-purity VWF using data from 74 patients and 99 surgeries, revealing substantial variability in treatment response and identifying key determinants such as age, bodyweight, blood group, and VWD type.
These findings support the development of personalized dosing strategies to improve perioperative management.
This collaborative work was co-led by Prof Sophie Susen (CHU de Lille) and Prof Xavier Delavenne (CHU de Saint-Étienne).
Congrats to Melanie Daniel, Camille Paris, Prof Antoine Rauch and colleagues.”
Title: Modeling response to high-purity von Willebrand factor: toward tailored dosing during surgery in von Willebrand disease
Authors: Mélanie Y. Daniel, Antoine Rauch, Camille Paris, Emmanuelle Jeanpierre, Jenny Goudemand, Catherine Marichez, Bénédicte Pradines, Christophe Zawadzki, Annabelle Dupont, Cécile V. Denis, Peter J. Lenting, Sophie Susen, Xavier Delavenne
Read the Full Article on Blood Advances
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 25, 2026, 18:36James P. Crowley: Gene Inactivation and Targeted Gene Repair as Two Approaches to CRISPR Gene Editing
-
Oct 25, 2026, 17:43Jan Sloves: Femoral Vein Aneurysm and Chronic Venous Obstruction
-
Oct 25, 2026, 17:31Kasimu Hussaini: Blood Component Therapy From Whole Blood to Targeted Treatment
-
Oct 25, 2026, 17:23Zahra Safarzadeh: When Low Factor VII Activity and Reduced VWF Antigen Coexist
-
Oct 25, 2026, 17:17Anubhav Joshi: Evans Syndrome in CLL A Differential Diagnosis to Remember
-
Oct 25, 2026, 17:04Tehila Alter: Tracking Hematopoietic Cell Engraftment in Bone Marrow Using CEST MRI
-
Oct 25, 2026, 16:45Shauna Riley։ First Guidelines for Hemoglobin SC Disease
-
Oct 25, 2026, 16:26Heghine Khachatryan: Patient Safety and Clinical Judgment in Platelet Transfusion Decisions
-
Oct 25, 2026, 16:13Funmi (Vanessa) Ullam: From Lived Experience to Research and Innovation in Sickle Cell Care