Mihaela Cordeanu: Can D-dimer Help Diagnose Splanchnic Vein Thrombosis?
Mihaela Cordeanu, Associate Professor and Hospital Practitioner in Vascular Medicine at Strasbourg University Hospital, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in JVS-Vascular Insights, adding:
“Can D-dimer help diagnose Splanchnic Vein Thrombosis?
Pleased to share our systematic review published in JVS-Vascular Insights, co-authored with Simon Soudet and Prof Dominique Stephan.
We analyzed 25 studies (9,052 patients) evaluating D-dimer diagnostic accuracy for SVT.
Key findings:
- Highly variable performance (sensitivity 54–95%, specificity 33–96%)
- Accuracy declines with worsening hepatic function, a clinical paradox, as advanced cirrhotic patients carry the highest PVT risk yet show the poorest D-dimer performance
- High negative predictive value only in selected low-risk populations (Child-Pugh A)
- Multimarker models (D-dimer and P-selectin or von Willebrand factor) outperform D-dimer alone but remain research tools
Bottom line: D-dimer cannot serve as a universal standalone rule-out test for SVT. Imaging remains the diagnostic cornerstone, consistent with major international guidelines.”
Title: D-dimer diagnostic performance for splanchnic vein thrombosis: A systematic review
Authors: Elena-Mihaela Cordeanu, Simon Soudet, Dominique Stephan
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 30, 2026, 22:28Recent Mechanical Risk Factors and Young-Onset Cryptogenic Ischemic Stroke – American Heart Association International
-
Sep 30, 2026, 22:22Expert Consensus on Inferior Vena Cava Thrombosis – Thrombosis and Haemostasis Journal
-
Sep 30, 2026, 22:21Markus Abeln: How Platelets and Complement Shape Placental Blood Flow
-
Sep 30, 2026, 22:19Fatma Al Arbawi: Studying Blood Clot Mechanics to Understand Aspirin Resistance and Thrombosis
-
Sep 30, 2026, 22:17Sudhir Kumar: Stroke is a Medical Emergency – and Every Minute Matters
-
Sep 30, 2026, 22:15Luisa Medeiros Visentini: Our Research on Cognitive Impairment After CVT Cited in the International Journal of Stroke
-
Sep 30, 2026, 21:50Jagat Narula: Connecting Cardiovascular Health and Sickle Cell Disease on World Heart Day 2026
-
Sep 30, 2026, 21:38John Kastelein: Exploring the Biology of Cardiovascular Disease at BioCentury Grand Rounds Europe
-
Sep 30, 2026, 21:36Mark Murphy: Irish Heart Foundation Meets With Senator Teresa Costello on World Heart Day