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Nathan Connell on Conversion from Eptacog Alfa to Beta
Nathan Connell/LinkedIn
Dec 15, 2025, 12:34

Nathan Connell on Conversion from Eptacog Alfa to Beta

Nathan Connell, Clinical Chief of Hematology at Brigham and Women’s Faulkner Hospital, shared on LinkedIn:

”New Research: Real-World Evidence on Recombinant Factor VIIa Substitution

I’m excited to share our team’s latest publication in Clinical Applied Thrombosis Clinical and Applied Thrombosis/Hemostasis.

We conducted a retrospective evaluation of our conversion from eptacog alfa (NovoSeven) to eptacog beta (Sevenfact) to assess both clinical safety and financial impact at Brigham and Women’s Hospital.

Key Findings:

  • Safety: The transition to eptacog beta showed no adverse thrombotic events across the patient cohort.
  • Efficacy: Effective management was maintained for indications including hemophilia bleeding and peri-procedural management.
  • Impact: The medication use evaluation identified an estimated cost avoidance of $554,400 over 12 months.

This study supports the viability of therapeutic interchange for rFVIIa products, offering a pathway for other institutions to maintain high-quality care while optimizing costs.”

Read the full article here.

Article: Real World Experience with use of Coagulation Factor VIIa at an Academic Medical Center

Authors: George AR, Sylvester KW, Kanaan DM, Reddy P, Fanikos JR, Connors JM, Connell NT

Nathan Connell on Conversion from Eptacog Alfa to Beta

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bleeding disorders Brigham and Women's Hospital Connell NT Connors JM eptacog alfa Eptacog Beta Fanikos JR George AR Health Hematology Hemophilia Hemostasis Hemostasis Today Kanaan DM Medicine NovoSeven Reddy P Sevenfact Sylvester KW
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