Nishant K Mishra։ When Epilepsy Meets Anticoagulation
Nishant K Mishra, Stroke Director at U.S. Department of Veterans Affairs, shared on LinkedIn about a recent article he and his colleagues co-authored, published in JAMA Neurology, adding:
”Pleased to share our new study in JAMA Neurology: ‘Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy.’
In this international real-world study of adults with epilepsy receiving direct oral anticoagulants (DOACs), antiseizure medication choice was associated with meaningful differences in thromboembolic, bleeding, and mortality outcomes.
Notably, compared with lamotrigine/lacosamide, levetiracetam was associated with a higher thromboembolic risk, as were strong enzyme-inducing antiseizure medications.
These findings raise an important and very practical question: When treating epilepsy in a patient who requires anticoagulation, could antiseizure medication selection itself be a modifiable contributor to vascular outcomes?
Congratulations to Kai Michael Schubert, Marian Galovic, and the entire international collaborative team. Grateful to have contributed to this work.”
Title: Safety of Antiseizure Medications During Direct Oral Anticoagulant Therapy in Epilepsy
Authors: Kai Michael Schubert, Carolina Ferreira-Atuesta, Arunachalam Soma, Johan Zelano, David J Seiffge, Francesco Brigo, Eugen Trinka, Nishant K Mishra, Emilio Russo, Gregory Y H Lip, Gashirai K Mbizvo, Marian Galovic
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