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Octavio Marques Pontes-Neto: A Landmark Step in Stroke Prevention from The TRIDENT Trial Findings
Octavio Marques Pontes-Neto/LinkedIn
Apr 24, 2026, 06:25

Octavio Marques Pontes-Neto: A Landmark Step in Stroke Prevention from The TRIDENT Trial Findings

Octavio Marques Pontes-Neto, Professor at Ribeirão Preto School of Medicine, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in The New England Journal of Medicine, adding:

“Honored to be part of the publication of the TRIDENT trial in the New England Journal of Medicine.

This landmark study showed that, among survivors of intracerebral hemorrhage, a single pill combining three low-dose antihypertensive agents reduced recurrent stroke and major cardiovascular events, reinforcing the central importance of sustained blood-pressure control after ICH.

Deeply proud of the participation of Brazilian investigators, including colleagues from multiple centers in the country: Sheila Cristina Ouriques Martins, Ana Cláudia de Souza, Rodrigo Bazan, Viviane Zetola and Carla Moro.

It is equally important to recognize that funding from the Brazilian Ministry of Health (Proadi Sus) was essential for the conclusion of this study, alongside Australian support.

This is a powerful example of how strategic public investment in clinical research can help generate evidence with global impact and direct relevance for patient care.

My sincere congratulations to Professor Craig Anderson for his outstanding leadership in bringing this important trial to completion and publication, and to Professor Sheila Cristina Ouriques Martins for her remarkable leadership and for helping ensure strong Brazilian engagement in a study of such global significance.

This is the kind of science that changes practice: rigorous, collaborative, international, and focused on improving outcomes in one of the most devastating forms of stroke.

Proud and grateful to have contributed to this effort.”

Title: Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage

Authors: Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Baza, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers

Octavio Marques Pontes-Neto: A Landmark Step in Stroke Prevention from The TRIDENT Trial Findings

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Ajantha Keshavaraj Ana Claudia de Souza Anderson Berni Cristofari Anthony Rodgers Anuradha Dahanayaka Athula Dissanayake Bimsara Senanayake Candice Delcourt Carla Heloisa Cabral Moro Carlos Delfino Catharina J.M. Klijn Cheryl Carcel Christopher Chen Clara K. Chow Craig S. Anderson Darshana Wijegunasinghe Dennis Cordato Devasmitha Wijesundara Dilum Palliyaguruge Feifeng Liu Floris H. Schreuder H. Asita de Silva Harsha Gunasekera Health Hematology Hemostasis News Hemostasis Today Hisatomi Arima Huy Thang Nguyen Indunil Wijeweera Janaka Peiris Jiguang Wang John Chalmers Karla Santo Kolawole Wahab Lauren Kuhles Laurent Billot Lili Song Luiz Nasi Maia Beridze Manuela Armenis Mariana Almudi Souza Mariana Battaglini Mark Woodward Mathangi Shanthakumar Medicine Michael Barnett Mythily Aravinthan Natalie Espinosa Neil Watson New England Journal of Medicine Nihara Abdul Rasheed Nilukshi Fernando Nodar Kakabadze Octávio Pontes-Neto Pramith Ruwanpathirana Qiang Li Qiao Han Reginald O. Obiako Richard I Lindley Rodrigo Baza Rohan Grimley Rufus Akinyemi Rustam Al-Shahi Salman Ruth Freed Sana Shan Senaka Bandusena Sharon L. Naismith Sheila Ouriques Martins Shoujiang You Sonali Liyanagamage stroke prevention Thambipillai Rajendiran Thompson Robinson Tim Wilkinson Tinatin Kherkheulidze Tom J. Moullaali TRIDENT Trial Tsong-Hai Lee Udaya K. Ranawaka Urs Fischer Vithoosan Sahathevan Viviane Zétola Wan Asyraf Wan Zaidi Wan Chung Law Wilmar M.T. Jolink Xia Wang Yuen Kang Chia Zien Zhou
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