Omer Mohammed: Functional Benefits and Bleeding Risks in Stroke Bridging Therapy
Omer Mohammed, Peer Reviewer at Cureus Journal of Medical Science, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in The American Journal of Cardiology:
“Its a pleasure to share that our meta-analysis (10,538 patients) on thrombolysis before thrombectomy in acute ischemic stroke is now published in The American Journal of Cardiology.
What started as a curious question was reformed into an oral presentation at Pan Arab Interventional Radiology Society last year and now as a full paper.
What we found:
- Bridging therapy does seem to help. Patients had better functional outcomes (RR 1.12), slightly higher reperfusion rates (RR 1.04), and lower mortality (RR 0.80).
But there’s a real trade-off with increased symptomatic intracranial hemorrhage.
The interesting part?
When you look only at RCTs, the advantage isn’t as clear.
Also, stroke severity and workflow metrics influenced the impact of bridging therapy.
Takeaway: this isn’t a ‘one protocol fits all’ situation.
Decisions should depend on workflow speed, stroke severity, and bleeding risk.
Always nice when the data reminds us that medicine is still about nuance.
I am grateful to the entire team who made this phenomenal work possible.”
Title: Safety and Efficacy of Thrombolysis Prior to Thrombectomy in Large-Vessel Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis
Authors: Omer Mohammed, Shilla Thomas, VS Sharon, Medhansh Biradar, Leroy D’Souza, Afthab Salam Kanniyan, Akiva Rosenzveig, Aravinda Nanjundappa, Shelby Kutty
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