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Pablo Corral: The Truth About Very Low LDL-Cholesterol
Pablo Corral/LinkedIn
May 12, 2026, 16:33

Pablo Corral: The Truth About Very Low LDL-Cholesterol

Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared a post on LinkedIn about a recent article by Luz Clemencia Zárate-Correa et al., published in Atherosclerosis, adding:

”Our last manuscript is out.

‘Safety of Very Low LDL-Cholesterol:

Ten Common Concerns, Misconceptions, and Evidence-Based Clarifications’

Very low LDL-C levels continue to generate debate, fear, and misinformation in clinical practice.

In this review, we critically examined 10 of the most frequent concerns related to intensive LDL-C lowering:

  •  Cognitive decline
  •  Hemorrhagic stroke
  •  Cancer
  •  Cataracts
  •  Hormonal dysfunction
  •  Diabetes risk
  •  Muscle symptoms
  •  Older adults
  •  Sex differences
  •  Overall cardiovascular benefit

The key message is clear:

RCTs, meta-analyses, and genetic evidence consistently support the safety profile of very low achieved LDL-C levels in appropriately selected high-risk patients.

  • Some adverse effects are real — particularly statin-associated dysglycemia and muscle symptoms — but their absolute risk is generally modest compared with the magnitude of ASCVD risk reduction.
  • Therapeutic inertia and misinformation remain major barriers in preventive cardiology. Evidence-based communication matters.
  • Lower LDL-C. Earlier. Longer. Safer than many still believe.

Proud to collaborate with outstanding colleagues from Latin America, Europe, and beyond in this international effort.”

Title: Safety of Very Low LDL-Cholesterol: Ten Common Concerns, Misconceptions, and Evidence-Based Clarifications

Authors: Luz Clemencia Zárate-Correa, Ángel García-Peña, Sergio Emanuel Kaiser, Carlos A. Aguilar-Salinas, Máxima Mendez-Castillo, Roopa Mehta, Cynthia M. Valerio, Rodrigo O. Moreira, Leonardo G. Mancillas-Adame, José Antonio Cetina Canto, Juan José Parcero, Ximena Reyes, Meral Kayikcioglu, Alexandros D. Tselepis, Laura Schreier, Pablo Corra

Pablo Corral: The Truth About Very Low LDL-Cholesterol

Other featuring Pablo Corral on Hemostasis Today.

Alexandros D. Tselepis Ángel García-Peña Carlos A. Aguilar-Salinas Cynthia M. Valerio Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today José Antonio Cetina Canto Juan José Parcero Laura Schreier Leonardo G. Mancillas-Adame Luz Clemencia Zárate-Correa Máxima Mendez-Castillo Medicine Meral Kayikcioglu Pablo Corra Pablo Corral Rodrigo O. Moreira Roopa Mehta Sergio Emanuel Kaiser Ximena Reyes
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