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Pablo Corral: Can One Infusion Lower LDL for Years

Pablo Corral/LinkedIn, Børge G. Nordestgaard/novonordiskfonden.dk

Aug 14, 2026, 10:49

Pablo Corral: Can One Infusion Lower LDL for Years

Pablo Corra, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared a post on LinkedIn about a recent article by Børge G. Nordestgaard et al., published in NEJM, adding:

“A glimpse into the future of LDL-C lowering: one infusion, potentially years of effect.

VERVE-102 uses in vivo base editing of PCSK9 aiming to reproduce the lifelong protection seen in carriers of PCSK9 loss-of-function variants.

Early Phase 1 results are striking:

35 patients with HeFH and/or premature CAD
Single IV infusion – no chronic dosing
At the highest dose (1.0 mg/kg):

PCSK9 decreased 88%

LDL-C decreased 62%

Absolute LDL-C reduction: −78 mg/dL

LDL-C fell from 128 to 51 mg/dL on average
Reductions appeared sustained, with grater than or equal to 1-year follow-up available in 15 patients
No dose-limiting toxicity or deaths; infusion reactions were generally mild/moderate, with transient ALT elevations reported.

Still Phase 1. Small numbers.

Long-term safety – including off-target editing – and cardiovascular outcomes remain unknown, with 15-year follow-up planned.

But the paradigm is provocative:

From ‘lower LDL-C for life’ to potentially ‘one treatment for lifelong LDL-C lowering.'”

Title: A New Approach to Lowering LDL Cholesterol

Author: Børge G. Nordestgaard

Pablo Corral: Can One Infusion Lower LDL for Years