NewsFeed Voices Science Insight Innovation
January, 2026
January 2026
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
Real-World Use of Protein C Concentrate in Protein C Deficiency
Paul Brons/LinkedIn
Nov 5, 2025, 05:24

Real-World Use of Protein C Concentrate in Protein C Deficiency

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:

”Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry By Marilyn Manco-Johnson, Paul Brons, Paul Knoebl, Michael Wang, Csaba Siffel, MD, PhD, Peter Turecek, and Hanna Gazda

  • Context: Protein C deficiency, congenital or acquired, predisposes to severe, recurrent thrombosis. Evidence for protein C concentrate use beyond case reports has been scarce.
  • Study: A prospective international registry (26 sites; Europe + USA) captured 43 patients treated between 2010–2015, documenting 306 courses of therapy for acute events, replacement, or long-term prophylaxis.
  • Findings: 76% of congenital cases were on long-term prophylaxis. Adverse events were infrequent; only one patienthad possibly related serious AEs. Real-world data affirm the safety and versatility of protein C concentrate across diverse indications.”

Title: Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry

Authors: Marilyn Manco-Johnson, Paul Brons, Paul Knoebl, Michael Wang, Csaba Siffel, Peter L. Turecek. Hanna T. Gazda

Protein C Deficiency

Read the article here.

Stay updated on all scientific advances with Hemostasis Today.

Csaba Siffel Hanna T. Gazda Health Hematology Hemostasis Today Journal of Thrombosis and Haemostasis JTH Marilyn Manco-Johnson Medicine Michael Wang Paul Brons Paul Knoebl Peter L. Turecek protein C Protein C Concentrate thrombosis
NewsFeed