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Real-World Use of Protein C Concentrate in Protein C Deficiency
Paul Brons/LinkedIn
Nov 5, 2025, 05:24

Real-World Use of Protein C Concentrate in Protein C Deficiency

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:

”Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry By Marilyn Manco-Johnson, Paul Brons, Paul Knoebl, Michael Wang, Csaba Siffel, MD, PhD, Peter Turecek, and Hanna Gazda

  • Context: Protein C deficiency, congenital or acquired, predisposes to severe, recurrent thrombosis. Evidence for protein C concentrate use beyond case reports has been scarce.
  • Study: A prospective international registry (26 sites; Europe + USA) captured 43 patients treated between 2010–2015, documenting 306 courses of therapy for acute events, replacement, or long-term prophylaxis.
  • Findings: 76% of congenital cases were on long-term prophylaxis. Adverse events were infrequent; only one patienthad possibly related serious AEs. Real-world data affirm the safety and versatility of protein C concentrate across diverse indications.”

Title: Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry

Authors: Marilyn Manco-Johnson, Paul Brons, Paul Knoebl, Michael Wang, Csaba Siffel, Peter L. Turecek. Hanna T. Gazda

Protein C Deficiency

Read the article here.

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Csaba Siffel Hanna T. Gazda Health Hematology Hemostasis Today Journal of Thrombosis and Haemostasis JTH Marilyn Manco-Johnson Medicine Michael Wang Paul Brons Paul Knoebl Peter L. Turecek protein C Protein C Concentrate thrombosis
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