Roberta Gualtierotti: rFVIIIFc and rFIXFc Ensured Effective Haemostasis and Favourable Safety in Major Orthopaedic Surgery
Roberta Gualtierotti, Associate Professor of Internal Medicine at University of Milan, shared on LinkedIn:
”Fc-fusion factors in orthopaedic surgery for haemophilia
Happy to share our experience at the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Ospedale Policlinico di Milano, Università degli Studi di Milano, and Florence Hemophilia Center, Azienda Ospedaliero-Universitaria Careggi.
Prospective study (2018–2023) on 20 major surgeries in 19 patients with haemophilia A or B treated with rFVIIIFc or rFIXFc.
- Haemostasis rated ‘good’ in 95% of cases
- No transfusions required
- No treatment-related adverse events
- we need more date to standardize and personalize perioperative schedule with EHL factors
Conclusion: rFVIIIFc and rFIXFc ensured effective haemostasis and favourable safety in major orthopaedic surgery.”
Title: Orthopaedic Surgery Outcomes in Patients With Haemophilia A or B Treated With Extended Half-Life Recombinant Factor VIII and IX Fc Fusion Proteins: A Multicentre Prospective Study
Authors: Luigi Piero Solimeno, Roberta Gualtierotti, Emanuele Guido, Jacopo Acquati Lozej, Enrica Cristini, Alessandro Ciavarella, Sara Arcudi, Christian Carulli, Lisa Pieri, Simona Maria Siboni, Flora Peyvandi
Read the full paper here.
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