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Roberta Gualtierotti: rFVIIIFc and rFIXFc Ensured Effective Haemostasis and Favourable Safety in Major Orthopaedic Surgery
Roberta Gualtierotti/LinkedIn
Oct 12, 2025, 07:28

Roberta Gualtierotti: rFVIIIFc and rFIXFc Ensured Effective Haemostasis and Favourable Safety in Major Orthopaedic Surgery

Roberta Gualtierotti, Associate Professor of Internal Medicine at University of Milan, shared on LinkedIn:

”Fc-fusion factors in orthopaedic surgery for haemophilia

Happy to share our experience at the Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Ospedale Policlinico di Milano, Università degli Studi di Milano, and Florence Hemophilia Center, Azienda Ospedaliero-Universitaria Careggi.

Prospective study (2018–2023) on 20 major surgeries in 19 patients with haemophilia A or B treated with rFVIIIFc or rFIXFc.

  • Haemostasis rated ‘good’ in 95% of cases
  • No transfusions required
  • No treatment-related adverse events
  • we need more date to standardize and personalize perioperative schedule with EHL factors

Conclusion: rFVIIIFc and rFIXFc ensured effective haemostasis and favourable safety in major orthopaedic surgery.”

Title: Orthopaedic Surgery Outcomes in Patients With Haemophilia A or B Treated With Extended Half-Life Recombinant Factor VIII and IX Fc Fusion Proteins: A Multicentre Prospective Study

Authors: Luigi Piero Solimeno, Roberta Gualtierotti, Emanuele Guido, Jacopo Acquati Lozej, Enrica Cristini, Alessandro Ciavarella, Sara Arcudi, Christian Carulli, Lisa Pieri, Simona Maria Siboni, Flora Peyvandi

Roberta Gualtierotti

Read the full paper here.

Stay updated on the latest scientific advancements with Hemostasis Today.

Alessandro Ciavarella Christian Carulli Emanuele Guido Enrica Cristini Factor VIII Flora Peyvandi haemophilia Haemostasis Headlines Health Hematology Hemostasis Hemostasis Today Jacopo Acquati Lozej Lisa Pieri Luigi Piero Solimeno Medicine Prospective Study rFIXFc rFVIIIFc Roberta Gualtierotti Sara Arcudi Simona Maria Siboni transfusion
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