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Samer Alsaid։ Older Patients With Atrial Fibrillation Benefit From FXI Inhibition
Samer Alsaid/LinkedIn
Feb 10, 2026, 14:54

Samer Alsaid։ Older Patients With Atrial Fibrillation Benefit From FXI Inhibition

Samer Alsaid, Cardiologist and Vascular Medicine Specialist, shared a post on LinkedIn  about a recent article he co-authored with his colleagues, adding:

՛՛Bleeding risk rises steadily with age in patients with atrial fibrillation — underscoring the need for safer anticoagulant options in older individuals.

In our prespecified analysis of the phase 2b AZALEA-TIMI 71 trial, now published in JAMA Cardiology, the FXI inhibitor abelacimab consistently reduced bleeding compared with rivaroxaban across age groups, with the potential for greater absolute reductions in older patients.

FXI inhibition may become a particularly attractive option for older patients with AF, but phase 3 trial results are needed to define its efficacy and overall benefit-risk balance.

Grateful to an outstanding group of collaborators, mentors, and the AZALEA-TIMI 71 investigators who made this work possible․՛՛

Title: Abelacimab vs Rivaroxaban in Older Individuals With Atrial Fibrillation

Authors: Samer Al Said, Siddharth M. Patel, Robert P. Giugliano, David A. Morrow, Erica L. Goodrich, Sabina A. Murphy, Bruce Hug, Sanobar Parkar, Shih-Ann Chen, Shaun G. Goodman, Boyoung Joung, Robert G. Kiss, Wojciech Wojakowski, Jeffrey I. Weitz, Dan Bloomfield, Marc S. Sabatine, Christian T. Ruff

Read the Full Article on JAMA Cardiology․

Samer Alsaid։ Older Patients With Atrial Fibrillation Benefit From FXI Inhibition

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Abelacimab AZALEA-TIMI 71 Boyoung Joung Bruce Hug Christian T. Ruff Dan Bloomfield David A. Morrow Erica L. Goodrich JAMA Cardiology Jeffrey I. Weitz Marc S Sabatine Robert G. Kiss Robert P. Giugliano Sabina A. Murphy Samer Al Said Sanobar Parkar Shaun G. Goodman Shih-Ann Chen Siddharth M. Patel Wojciech Wojakowski
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