Violeta Jardin: Measuring Antifibrinolytic Effect to Improve Tranexamic Acid Safety
Violeta Jardin, General Manager at Haemoview Diagnostics, shared a post on LinkedIn about a recent article by Kaiki Oya et al, published in A and A Practice, adding:
“Tranexamic acid (TXA) is central to bleeding control in cardiac surgery, yet high cumulative dosing around cardiopulmonary bypass is linked to perioperative seizures and prolonged antifibrinolytic shutdown, particularly in patients with renal impairment.
This new case report of TXA-induced seizure immediately after CPB highlights the need for individualized TXA strategies and real-time assessment of its neuro- and haemostatic impact.
The ClotPro TPA-test offers the only viscoelastic quantification of TXA-induced inhibition of tPA-triggered fibrinolysis, allowing titration to effect rather than fixed dosing and supporting safer, lower-dose TXA regimens in high‑risk patients.
Yoshii et al. show that even a 1 g TXA bolus produces measurable, sustained antifibrinolytic activity, with TPA-test parameters closely tracking impaired eGFR—providing a practical tool to avoid TXA overdosing and balance bleeding, seizure, and thrombotic risk post‑cardiac surgery.”
Title: Tranexamic Acid-Induced Seizure After Cardiopulmonary Bypass: A Case Report
Authors: Kaiki Oya, Jun Maki, Midoriko Higashi
Read the Full Article on British Journal of Anaesthesia.
Title: Point-of-care testing for tranexamic acid efficacy: a proof-of-concept study in cardiac surgical patients
Authors: Ryogo Yoshii, Yuya Takahashi, Kenichi A. Tanaka, Hidetake Kawajiri, Teiji Sawa, Fumimasa Amaya, Satoru Ogawa
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 28, 2026, 16:43Scott Sutton: Community and Connection in Immune Thrombocytopenia
-
Sep 28, 2026, 16:24Pankti Solanki: ISBT Recognized JAMA as the 49th Human Blood Group System
-
Sep 28, 2026, 15:52Kassa Tameru: Antithrombotic Management in GI Bleeding and Elective Endoscopy
-
Sep 28, 2026, 15:51Chengappa Kavadichanda: How Do aPLs Change Over Time in Early Lupus?
-
Sep 28, 2026, 15:18Linda Shore-Lesserson: Celebrating 25 Years of PBM at the SABM Meeting
-
Sep 28, 2026, 14:45Access Real-Time Bleeding Disorder Guidelines with the New WFH Resource Hub – WFH
-
Sep 28, 2026, 14:44Subham Banerjee: When Routine Blood Grouping Hid a Rare Diagnosis
-
Sep 28, 2026, 14:41Francois Roubille: Can Low-Dose Colchicine Prevent Atrial Fibrillation After CABG?
-
Sep 28, 2026, 14:39William Aird: Gulliver’s Atlas – Mapping the Evolution of the Vertebrate Red Cell