Vipin M. Vashishtha: Mild COVID-19 and Malaria Leave Measurable Fingerprints on the Clotting System
Vipin M. Vashishtha, Past Covener, ACVIP IAP at Indian Academy of Pediatrics, shared a post on X about a recent article by Erens Spiff Ekprikpo et al., published in PLOS Global Public Health, adding:
“Even mild infections can leave measurable fingerprints on the blood-clotting system.
A case-control study of 220 adults in Nigeria compared mild COVID-19, malaria, co-infection and healthy controls.
All three infected groups showed increased platelet-size variability, while D-dimer levels were highest in people with both infections. Clotting-related markers also showed sex-specific differences.
Two very different pathogens — a virus and a parasite — can disturb the body’s clotting balance, and when they strike together, the effects on clot formation and breakdown may be greater.
Why it matters: In malaria-endemic regions, even apparently mild infections may alter haemostasis. However, this small observational study measured biomarkers—not clinical clotting events—so it does not establish that these changes cause thrombosis.”
Title: Sex-specific hemostatic responses and alterations of Platelet Distribution Width (PDW) and D-dimer in mild COVID-19, Malaria, and co-infection in a tropical setting: A case-control study in Port Harcourt, Nigeria
Authors: Erens Spiff Ekprikpo, Stella Urekweru Ken-Ezihuo, Zaccheaus Awortu Jeremiah
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