Weam Aldiban: The Critical Impact of Pharmacogenetic Variation on Dabigatran Exposure and Bleeding Risk
Weam Aldiban, Head of Pharmacology & Toxicology Department at IUST University, shared a post on LinkedIn:
“Excited to share our latest publication in Human Genomics!
Title: The role of ABCB1 and CES1 genotypes on the efficacy and safety of dabigatran: a systematic review and meta-analysis
Our study highlights the critical impact of pharmacogenetic variation on dabigatran exposure and bleeding risk. Key findings include:
– ABCB1 rs/148738 CT/TT genotypes → lower trough concentrations
– CES1 rs8192935 GG genotype → increased peak concentrations
– CES1 rs2244613 TT genotype → elevated peak/trough levels and bleeding risk
– CES1 rs2244613 GT genotype → increased trough levels only
These insights underscore the importance of personalized medicine in anticoagulant therapy and call for large-scale prospective studies across diverse populations to validate and expand upon our findings.
Grateful to our team and collaborators for their dedication and rigor. Let’s keep pushing the boundaries of precision pharmacotherapy!”
Title: The role of ABCB1 and CES1 genotypes on the efficacy and safety of dabigatran: a systematic review and meta-analysis
Authors: Weam Aldiban, Nada G. Hamam, Nereen A. Almosilhy, Kholoud Elsamman, Mohamed Wagdy, Doaa Mashaly, Suhel F. Batarseh, Youssef El-Sherif, Basma Badrawy Khalefa, Zina Otmani
Read full paper here.
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