Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
August, 2026
August 2026
M T W T F S S
 12
3456789
10111213141516
17181920212223
24252627282930
31  
Wolfgang Miesbach Shares Real-World Evidence on Eptacog Beta from Spain
Wolfgang Miesbach/LinkedIn
Nov 19, 2025, 17:02

Wolfgang Miesbach Shares Real-World Evidence on Eptacog Beta from Spain

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:

”Eptacog Beta Beyond Labels: Spanish Real-World Evidence

  • 8 patients | 2 Madrid centres | 3 rare bleeding disorders
  • On-Label Treatments (HA + Inhibitors; n=4)
  • 3/4 on concurrent emicizumab (excluded from PERSEPT trials)
  • Dosing: 75 µg/kg
  • Breakthrough control + thrombotic safety
  • Severe iliopsoas haematoma: 70 infusions → complete resolution, zero thrombotic events

Off-Label Treatments (n=4)

  • Factor VII deficiency (n=3): Perioperative surgery with 15–20 µg/kg—excellent haemostasis, zero bleeding complications
  • Steroid-refractory acquired haemophilia (n=1): High-titre inhibitor case reflects poor-prognosis disease biology

No Safety Signal: Zero thrombotic/thromboembolic complications across all patients

As emicizumab, concizumab, marstacimab and fitusiran transform prophylaxis of haemophilia, eptacog beta emerges as a versatile rescue therapy.

This real-world experience expands treatment paradigms beyond current labels—pending validation from further studies.

Congratulations to the authors!”

Read the full article here.

Article: Real-World Experience with Eptacog Beta for On-Label and Off-Label Indications: The Spanish Experience

Authors: Jose Manuel Martin de Bustamante, María Isabel Rivas-Pollmar, Natalia Acedo, Nora Butta, Victor Jimenez-Yuste, Maria Teresa Álvarez-Román

Wolfgang Miesbach Shares Real-World Evidence on Eptacog Beta from Spain

Stay updated on all scientific advances with Hemostasis Today.

bleeding disorders Concizumab Emicizumab Eptacog Beta Health Hematology Hemophilia Hemostasis Hemostasis Today iliopsoas haematoma Jose Manuel Martin de Bustamante María Isabel Rivas-Pollmar Maria Teresa Álvarez-Román marstacimab and fitusiran MDPI Medicine Natalia Acedo Nora Butta Spain thrombosis Víctor Jiménez-Yuste Wolfgang Miesbach
NewsFeed