Wolfgang Miesbach: Potential Transmission of Haemorrhagic Risk Through Blood Transfusion
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared post on LinkedIn about a recent article by Gargi Banerjee et al., published in The Lancet, adding:
”Haemorrhage risk appears transferrable from blood donor to recipient. A Lancet Viewpoint from a workshop convened by the MRC Prion Unit at UCL in 2024, with clinicians, epidemiologists and transfusion specialists:
Amyloid β (Aβ) propagates by templated seeding, the mechanism of the prion protein. It circulates in plasma, comes from platelets, binds to red cells. In rodents, blood from amyloid-bearing animals seeds cerebral amyloidosis in the recipient.
Denmark and Sweden, 1.27 million donors and 1.09 million recipients: recipients of red cells from donors who later had repeated intracerebral haemorrhages, the pattern typical of cerebral amyloid angiopathy, had a higher haemorrhage risk themselves. Registry data only, no imaging, no histology.
Open questions: are plasma-derived products, including factor concentrates, affected?
Not yet examined. Latency unknown.
No assay measures Aβ seeds in plasma. p-tau217 could screen donors, but the meaning of a positive result in a healthy donor is undefined.”
Title: Risk of transmission of amyloid β pathology via transfused blood products
Authors: Gargi Banerjee, Gustaf Edgren, Jingcheng Zhao, Prof Neil M Ferguson, Prof Heli Harvala, James Hope, Graham S Jackson, Prof Philip J Lowry, Prof Simon Mead, Silvia A Purro, Prof Jonathan M Schott, Prof Marc L Turner, Prof David J Werring, Prof Henrik Zetterberg, Prof John Collinge
Other posts featuring Wolfgang Miesbach on Hemostasis Today.
-
Oct 13, 2026, 02:01Nour Al-Mozain: Is It Really Anti-D? – Unraveling Auto-Anti-LW in the Transfusion Laboratory
-
Oct 13, 2026, 01:51Berenice Villegas: The Role of Morphologic Evaluation in Body Fluid Differential Analysis
-
Oct 13, 2026, 01:44Debadrita Ray: Evaluating vWF and VITRO Score for Detecting CSPH in cACLD Patients
-
Oct 13, 2026, 01:34Nagesh Ramesh: Donating Blood for International Plasma Awareness Week
-
Oct 12, 2026, 21:51Sam Botchey: Orthobiologics Are Advancing but the Evidence Must Keep Pace
-
Oct 12, 2026, 21:50Serum Vitamin D, Platelet Function, and Bleeding in Primary ITP – Platelets Journal
-
Oct 12, 2026, 21:30Nika Samadzadeh Tabrizi: Looking Forward to the PACeS Trial on Anticoagulation for POAF
-
Oct 12, 2026, 21:28Michael Megaly: Does Coronary Ectasia Affect Outcomes in Acute Coronary Syndromes?
-
Oct 12, 2026, 21:25Vitor Borin P. de Souza: Think Twice Before Anticoagulating an Isolated Subsegmental PE