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Roberta Gualtierotti: We Evaluated Different Variables of the Cleaved HK Method in C1-Inhibitor Defects
Oct 10, 2025, 12:18

Roberta Gualtierotti: We Evaluated Different Variables of the Cleaved HK Method in C1-Inhibitor Defects

Roberta Gualtierotti, Associate Professor of Internal Medicine at University of Milan, shared on LinkedIn:

”Conflicting results have been reported in plasma measurement of cleaved high molecular weight kininogen (HK).
In our study, we evaluated different variables of the cleaved HK method in C1-inhibitor defects.

Reliable results were obtained when using protease inhibitors and precast gels.

Discover more details in our newly published paper!”

Title: Measurement of cleaved high-molecular-weight kininogen in patients with hereditary angioedema due to C1-inhibitor deficiency: preanalytical and analytical optimization

Authors: Chiara Suffritti, Roberta Gualtierotti, Andrea Zanichelli, Matteo Vidali, Massimo Cugno

Roberta Gualtierotti

Read the full article here.

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