Caroline Dixon and Colleagues on LMWH Dosing to Reduce The Risk of VTE in Pregnant Women With Inherited ATD
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:
”Anti-Xa–directed low-molecular-weight heparin dosing to reduce venous thromboembolism in pregnant women with inherited antithrombin deficiency
By Caroline Dixon, Karen Breen, Sue Robinson, Aine McCormick, and Professor Beverley Hunt OBE
• Challenge: Inherited antithrombin deficiency (ATD) markedly increases VTE risk during pregnancy, but LMWH efficacy depends on antithrombin levels.
• Approach: A single-centre cohort (32 pregnancies, 17 women) adopted anti-Xa-guided LMWH dosing with selective peripartum antithrombin concentrate.
• Outcome: Overall VTE rate was 12.5%, yet no VTE occurred in adherent women receiving anti-Xa–adjusted LMWH. Haemorrhage risk remained acceptable (12.5%, mostly moderate).”
Read the full article in JTH.
Article: Anti-Xa directed low-molecular-weight heparin dosing to reduce the risk of venous thromboembolism in pregnant women with inherited antithrombin deficiency
Authors: Caroline Dixon, Karen Breen, Susan Robinson, Aine McCormick, Beverley J. Hunt
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