Eric Goffin: Complement Activation Is the Hallmark of Atypical HUS
Eric Goffin, Head of the Nephrology at Cliniques Universitaires St-Luc, shared on LinkedIn:
”Uncontrolled complement activation: the hallmark of atypical hemolytic uremic syndrome (aHUS).
This rare but severe condition causes microvascular thrombosis, hemolysis, and kidney failure. Understanding why and who is affected is key to saving lives.
A new study from the Belgian cohort of the Global aHUS Registry just brought valuable answers !
- Massart A. et al., Journal of Nephrology (2025)
- Key insights:
- 121 Belgian patients (≈10.4 per million)
- 58% were women
- 1 in 3 carried a complement gene variant or anti-CFH antibodies
- Main genes involved: CFH, C3, and CD46
These real-world data deepen our understanding of aHUS and highlight the importance of personalized diagnostics and targeted complement therapies.”
Read the full article here.
Title: Clinical and genetic characteristics of patients diagnosed with atypical hemolytic uremic syndrome (aHUS): epidemiological data from the Belgian cohort of the Global aHUS Registry
Authors: Annick Massart, Laurent Weekers, Kathleen J. Claes, Tess Van Meerhaeghe, Evelien Snauwaert, Djalila Mekahli, Eric Goffin, Laure Collard, Nathalie Godefroid, Brigitte Adams, Stefan Van Cauwelaert, Koenraad Van Hoeck, Sebastien Block, Imad Al-Dakkak, Karin Dahan, Patrick Stordeur, Johan Vande Walle
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