Pablo Corral: “The lower, The better” Applies to The Brain Too
Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, posted on LinkedIn:
”Lower LDL-C, Lower Risk – Safely
New analysis from FOURIER & FOURIER-OLE (Monguillon et al., Circulation 2025):
In patients with prior ischemic stroke, achieving LDL-C <40 mg/dL led to a continuous reduction in MACE and recurrent stroke, without any increase in hemorrhagic stroke.
- 5,291 stroke patients
- Follow-up up to 7 years
- Stepwise reduction in cardiovascular and ischemic events with lower LDL-C
- Hemorrhagic strokes: rare and unrelated to LDL-C
Conclusion: Very low LDL-C levels (<40 mg/dL) are both effective and safe for secondary prevention after stroke – confirming that “the lower, the better” also applies to the brain.”
Read the full article here.
Title: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke
Authors: Victorien Monguillon, Peter Kelly, Michelle L. O’Donoghue, Jeong-Gun Park, Erin A. Bohula, Jeffrey L. Saver, Dan Atar, Anthony C. Keech, Peter S. Sever, Huei Wang, Gabriel Paiva da Silva Lima, Marc S. Sabatine, Robert P. Giugliano
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