Pablo Corral on Enlicitide: The Phase 3 CORALreef HeFH Trial Brings a Major Step Forward
Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared on LinkedIn:
”Breaking from AHA25
The phase 3 CORALreef HeFH trial brings a major step forward: the first oral PCSK9 inhibitor, enlicitide, cuts LDL-C by ≈60% vs placebo in adults with heterozygous familial hypercholesterolemia already on maximally tolerated statins.
- LDL-C ↓58% at 24 weeks and sustained −55% at 52 weeks
- ApoB ↓48%, non-HDL-C ↓52%, Lp(a) ↓25%
- >70% reached LDL < 70 mg/dL, with excellent tolerability
- No excess in adverse events vs placebo
Enlicitide (oral PCSK9 inhibitor, 20 mg QD) shows efficacy comparable to injectable antibodies — potentially transforming lipid management for HeFH and beyond. doi:10.1001/jama.2025.20620”
Read the full article here.
Article: Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia
Authors: Christie M. Ballantyne, Laura Gellis, Jean-Claude Tardif, Puja Banka, Ann Marie Navar, Emil Andreas Asprusten, Russell Scott, Erik S. G. Stroes, Samar Froman, Geraldine Mendizabal, Fan Wang, Alberico L. Catapano
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